INT254678

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) kinase activity (Map2k2)
Anatomy Link Frequency
colon 2
Map2k2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 21 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 135 99.60 Very High Very High Very High
Cancer 108 90.68 High High
Metastasis 30 89.52 High High
Carcinoma 12 82.68 Quite High
Adenoma 6 82.08 Quite High
Colorectal Cancer 6 69.68 Quite High
Aberrant Crypt Foci 3 58.64 Quite High
Breast Cancer 3 51.20 Quite High
Stress 3 47.92 Quite Low
Infection 21 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analysis under electrophoresis conditions that partially resolve the two isoforms indicates that both MEK1 and MEK2 are phosphorylated in human colon carcinoma cell lines (Fig. 6A).
Phosphorylation (phosphorylated) of MEK2 in colon associated with colon cancer
1) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.80 Pain Relevance 0
Immunohistochemistry analysis of a colorectal cancer tissue microarray containing over 400 colorectal cancer and 50 normal colon tissue biopsies revealed that 44% of colorectal cancers display high cytoplasmic expression of phosphorylated MEK1/MEK2 as compared to 10% of normal tissues (analysis to be published elsewhere).
Phosphorylation (phosphorylated) of MEK2 in colon associated with colon cancer
2) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.52 Pain Relevance 0
The best-characterized of the Ras effector pathways is the activation of the Raf family Ser/Thr kinases, leading to sequential phosphorylation and activation of MEK1/MEK2 and the mitogen-activated protein (MAP) kinases ERK1/ERK2 [8].
Phosphorylation (phosphorylation) of MEK2
3) Confidence 0.51 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.89 Pain Relevance 0

General Comments

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