INT254682

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) kinase activity (Map2k2)
Map2k2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 21 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 135 93.04 High High
Apoptosis 24 64.52 Quite High
Adhesions 6 10.24 Low Low
Death 6 9.12 Low Low
Metastasis 30 5.40 Low Low
Cancer 108 5.00 Very Low Very Low Very Low
Adenocarcinoma 24 5.00 Very Low Very Low Very Low
Intestinal Cancer 24 5.00 Very Low Very Low Very Low
Infection 21 5.00 Very Low Very Low Very Low
Carcinoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the effect of 5 distinct shRNAs for MEK1 and 3 shRNAs for MEK2, using as control a GFP-encoding vector.
Regulation (effect) of MEK2
1) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.37 Pain Relevance 0
As shown by immunoblot analysis, lentivirus-mediated delivery of MEK1 shRNAs resulted in complete silencing of MEK1 expression with no effect on MEK2, whereas the two MEK2 shRNAs markedly knocked-down MEK2 expression without affecting MEK1 isoform (Fig. 6B).
Neg (no) Regulation (effect) of MEK2
2) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.18 Pain Relevance 0
To assess the individual roles of MEK1 and MEK2, we expressed short-hairpin (sh) RNAs specifically targeting MEK1 or MEK2 gene in HCT116 cells using VSV-pseudotyped lentiviral vectors.
Regulation (targeting) of MEK2
3) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.44 Pain Relevance 0

General Comments

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