INT254695

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mcl1) cytosol (Map2k2) mitochondrion (Mcl1)
nucleus (Mcl1) kinase activity (Map2k2) cytoplasm (Mcl1)
Anatomy Link Frequency
IEC-6 2
Map2k2 (Mus musculus)
Mcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 30.20 Quite Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 98.76 Very High Very High Very High
Adhesions 2 74.84 Quite High
Death 2 73.72 Quite High
Metastasis 10 70.00 Quite High
Cancer 36 63.04 Quite High
Colon Cancer 45 38.64 Quite Low
Adenocarcinoma 8 5.00 Very Low Very Low Very Low
Intestinal Cancer 8 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low
Carcinoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive activation of MEK1 or MEK2 resulted in the up-regulation of the pro-survival proteins Mcl-1, Bcl-2 and, to a lesser extent, Bcl-xL in IEC-6 cells (Fig. 5B).
Positive_regulation (activation) of MEK2 in IEC-6 Regulation (regulation) of Mcl-1
1) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.84 Pain Relevance 0

General Comments

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