INT254704

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Map2k1, MAPK1) Golgi apparatus (Map2k1, MAPK1) cytoplasm (Map2k1, MAPK1)
cytosol (Map2k1, MAPK1) cytoskeleton (Map2k1, MAPK1) nucleoplasm (MAPK1)
Anatomy Link Frequency
colon 3
Map2k1 (Mus musculus)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 14 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 100.00 Very High Very High Very High
Hyperplasia 4 100.00 Very High Very High Very High
Colon Cancer 90 99.44 Very High Very High Very High
Apoptosis 16 78.80 Quite High
Cancer 72 77.68 Quite High
Leukemia 2 66.16 Quite High
Solid Tumor 2 65.60 Quite High
Skin Cancer 2 58.64 Quite High
Infection 14 51.20 Quite High
Carcinoma 8 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, a recent report has shown that activated MEK1 but not MEK2 can promote epidermal hyperplasia in transgenic mice, even though both MEK proteins trigger ERK1/ERK2 phosphorylation [16].
Neg (5524) Positive_regulation (activated) of MEK1 Positive_regulation (trigger) of Phosphorylation (phosphorylation) of ERK2 associated with targeted disruption and hyperplasia
1) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.91 Pain Relevance 0
Several human colon carcinoma cell lines display constitutive phosphorylation of ERK1/ERK2 MAP kinases [20], likely resulting from activation of MEK1/MEK2.
Positive_regulation (activation) of MEK1 in colon Positive_regulation (resulting) of Phosphorylation (phosphorylation) of ERK2 in colon associated with colon cancer
2) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.52 Pain Relevance 0

General Comments

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