INT254704

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.43 Pain Relevance 0

nucleus (Map2k1, MAPK1) Golgi apparatus (Map2k1, MAPK1) cytoplasm (Map2k1, MAPK1) cytosol (Map2k1, MAPK1) cytoskeleton (Map2k1, MAPK1) nucleoplasm (MAPK1)

Anatomy Link Frequency colon 3 Map2k1 (Mus musculus) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 5.00 Perioperative pain 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 8 100.00 Hyperplasia 4 100.00 Colon Cancer 90 99.44 Apoptosis 16 78.80 Cancer 72 77.68 Leukemia 2 66.16 Solid Tumor 2 65.60 Skin Cancer 2 58.64 Infection 14 51.20 Carcinoma 8 50.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Intriguingly, a recent report has shown that activated MEK1 but not MEK2 can promote epidermal hyperplasia in transgenic mice, even though both MEK proteins trigger ERK1/ERK2 phosphorylation [16].

Neg (5524) Positive_regulation (activated) of MEK1 Positive_regulation (trigger) of Phosphorylation (phosphorylation) of ERK2 associated with targeted disruption and hyperplasia

1) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.91 Pain Relevance 0

Several human colon carcinoma cell lines display constitutive phosphorylation of ERK1/ERK2 MAP kinases [20], likely resulting from activation of MEK1/MEK2.

Positive_regulation (activation) of MEK1 in colon Positive_regulation (resulting) of Phosphorylation (phosphorylation) of ERK2 in colon associated with colon cancer

2) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.52 Pain Relevance 0

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