INT254724

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.92
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 123 99.68 Very High Very High Very High
antagonist 6 92.04 High High
intrathecal 3 85.28 High High
rheumatoid arthritis 15 83.32 Quite High
depression 3 81.92 Quite High
psoriasis 3 70.92 Quite High
Arthritis 12 68.60 Quite High
Demyelination 1 64.56 Quite High
anesthesia 1 61.36 Quite High
vincristine 2 46.60 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 88 99.54 Very High Very High Very High
Obstructive Sleep Apnea 1 95.04 Very High Very High Very High
Encephalopathy 3 91.28 High High
Disease 26 90.20 High High
Hypercapnia 2 90.20 High High
Malaria 66 88.84 High High
Lung Cancer 6 88.56 High High
Pulmonary Disease 6 87.08 High High
Rheumatoid Arthritis 15 83.32 Quite High
Depression 1 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methotrexate (MTX) is a cell cycle-specific agent that inhibits the enzyme dihydrofolate reductase, preventing the conversion of folic acid to tetrahydrofolic acid and inhibiting cell replication.
Negative_regulation (inhibits) of dihydrofolate reductase associated with methotrexate
1) Confidence 0.42 Published 2007 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2596356 Disease Relevance 1.68 Pain Relevance 0.57
Because the anticancers MTX, aminopterin and pemetrexate, all inhibitors of DHFR enzymes, are active against P. falciparum, other anticancer inhibitors of DHFR, such as edatrexate, pralatrexate, and piritrexim might also be active against P. falciparum.
Negative_regulation (inhibitors) of DHFR associated with methotrexate
2) Confidence 0.36 Published 2010 Journal Trends in Parasitology Section Body Doc Link PMC2927876 Disease Relevance 0.62 Pain Relevance 0.10
The toxicity of MTX is a result of inhibition of the DHFR enzyme in normal cells.
Negative_regulation (inhibition) of DHFR enzyme associated with toxicity and methotrexate
3) Confidence 0.36 Published 2010 Journal Trends in Parasitology Section Body Doc Link PMC2927876 Disease Relevance 1.11 Pain Relevance 0.64
Because the anticancers MTX, aminopterin and pemetrexate, all inhibitors of DHFR enzymes, are active against P. falciparum, other anticancer inhibitors of DHFR, such as edatrexate, pralatrexate, and piritrexim might also be active against P. falciparum.
Negative_regulation (inhibitors) of DHFR associated with methotrexate
4) Confidence 0.36 Published 2010 Journal Trends in Parasitology Section Body Doc Link PMC2927876 Disease Relevance 0.51 Pain Relevance 0.09

General Comments

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