INT25475

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.30
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPC6)
Anatomy Link Frequency
platelet 1
TRPC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 99.84 Very High Very High Very High
TRP channel 8 98.56 Very High Very High Very High
Neurotransmitter 2 96.60 Very High Very High Very High
adenocard 1 94.60 High High
tolerance 1 82.68 Quite High
vanilloid receptor subtype 1 2 81.52 Quite High
agonist 12 74.84 Quite High
Pain 1 50.88 Quite High
antagonist 4 36.60 Quite Low
addiction 8 10.52 Low Low
Disease Link Frequency Relevance Heat
Prostate Cancer 5 95.36 Very High Very High Very High
Pain 1 50.88 Quite High
Diuresis 1 49.20 Quite Low
Benign Prostatic Hypertrophy 1 44.64 Quite Low
Targeted Disruption 6 38.08 Quite Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Adhesions 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Neutrophil Disorders 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the hypothesis that platelet-derived growth factor (PDGF)-mediated PASMC growth involves upregulation of c-Jun and TRPC6, a transient receptor potential cation channel.
Positive_regulation (upregulation) of TRPC6 in platelet associated with member 8
1) Confidence 0.64 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12529250 Disease Relevance 0 Pain Relevance 0.10
After the administration of the microcapsules there was a biphasic increase in D-Trp-6-LH-RH serum levels.
Positive_regulation (increase) of Trp-6
2) Confidence 0.45 Published 1989 Journal Prostate Section Abstract Doc Link 2526325 Disease Relevance 0.30 Pain Relevance 0.13
Coexpression of CaM1234 abolished TRPC6 activation secondary to Gq protein-coupled receptor activation or diacylglycerol application [31], [32] and strongly decreased activation of the adenosine diphosphoribose-sensitive channel TRPM2 [33], [34].
Positive_regulation (activation) of TRPC6 associated with adenocard
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.10
As it has been demonstrated that diacylglycerol analogs cannot activate TRPC3 and TRPC6 channels through stimulation of PKC, diacylglycerol could itself regulate TRPC3 and TRPC6 directly [91].
Positive_regulation (activate) of TRPC6
4) Confidence 0.29 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
More precisely, it is generally accepted that TRPC1, TRPC4, and TRPC5 are activated by Ca2+ store depletion [55565758596061], and TRPC3, TRPC6, and TRPC7 are directly activated by diacylglycerol and its cell-permeant analogs in an InsP3-R-independent manner [6263646566].
Positive_regulation (activated) of TRPC6
5) Confidence 0.27 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
Positive_regulation (activation) of TRPC6
6) Confidence 0.22 Published 1999 Journal Nature Section Title Doc Link 9930701 Disease Relevance 0 Pain Relevance 0.11
We find that hTRPC6 is a non-selective cation channel that is activated by diacylglycerol in a membrane-delimited fashion, independently of protein kinases C activated by diacylglycerol.
Positive_regulation (activated) of hTRPC6
7) Confidence 0.19 Published 1999 Journal Nature Section Abstract Doc Link 9930701 Disease Relevance 0 Pain Relevance 0.12

General Comments

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