INT254790

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
nucleus 1
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 59.72 Quite High
metalloproteinase 3 21.52 Low Low
cytokine 7 13.20 Low Low
Inflammation 8 8.48 Low Low
fibrosis 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 52 89.84 High High
Osteoarthritis 96 59.72 Quite High
Aging 13 59.44 Quite High
Death 15 52.88 Quite High
Atherosclerosis 35 38.88 Quite Low
Disease 13 17.36 Low Low
INFLAMMATION 7 8.48 Low Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activated receptor Smads form a complex with the co-Smad, Smad4 - this complex translocates to the nucleus and modifies gene expression.
Localization (translocates) of Smad4 in nucleus
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.17 Pain Relevance 0.06
induces a rapid activation of Smad pathway, characterized by increased phosphorylation of the regulatory Smads (Smad2/3) after 20 min, binding to Smad4 and nuclear translocation of the complex [4].
Localization (translocation) of Smad4
2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.37 Pain Relevance 0

General Comments

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