INT254795

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdc42) plasma membrane (Cdc42) cytoskeleton (Cdc42)
intracellular (Cdc42) GTPase activity (Cdc42) cytoplasm (Cdc42)
Cdc42 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 42.04 Quite Low
ischemia 2 39.76 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 51 92.96 High High
Stress 2 91.84 High High
Cancer 86 88.04 High High
Atherosclerosis 35 86.00 High High
Lung Cancer 1 66.32 Quite High
Neuroendocrine Cancer 1 61.28 Quite High
Colorectal Cancer 4 58.04 Quite High
Metastasis 3 56.68 Quite High
Hemangiosarcoma 2 53.32 Quite High
Increased Venous Pressure Under Development 2 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, these results can be similarly reproduced using RhoA/ROCK inhibitors (by DN-RhoA transfection, C3 pretreatment or ROCK inhibition with Y-27632), but not inhibiting other geranylated GTPases such as Rac1 or Cdc42.
Negative_regulation (inhibiting) of Cdc42
1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.70 Pain Relevance 0
RhoA, Cdc42 and Rac1 can be activated when GTP-bound, and inactivated, when GDP-bound.
Negative_regulation (inactivated) of Cdc42
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.83 Pain Relevance 0

General Comments

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