INT254811

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
cytoplasm (Col1a1)
Anatomy Link Frequency
fibrocartilage 1
Col1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 27 81.12 Quite High
fibrosis 31 74.08 Quite High
Inflammation 16 69.68 Quite High
antagonist 4 50.00 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 1 82.72 Quite High
Renal Disease 8 80.04 Quite High
Atrophy 2 76.24 Quite High
Fibrosis 33 74.08 Quite High
Diabetes Mellitus 6 74.04 Quite High
INFLAMMATION 18 69.68 Quite High
Chronic Renal Failure 2 67.84 Quite High
Ureteral Obstruction 16 61.20 Quite High
Disease 3 59.80 Quite High
Atherosclerosis 35 54.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two investigators scored each biopsy under blind conditions, and classified them: as hyaline-like cartilage when round cells in lacunae were in clusters and columns, and collagen fibrils, mainly of type II collagen (very intense), were parallel to the surface; as fibrocartilage when cells with rounded morphology and collagen type I fibrils (very intense) were localized randomly; or as mixed tissues when hyaline-like tissue and fibrocartilage-like tissue were present, with a moderate content of collagen type II (intense).
Localization (localized) of collagen type I in fibrocartilage
1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656234 Disease Relevance 0 Pain Relevance 0
to induce Col-1 secretion (Figure 7b).
Localization (secretion) of Col-1
2) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.11 Pain Relevance 0
activation reduced type I collagen synthesis and secretion.
Localization (secretion) of type I collagen
3) Confidence 0.10 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 1.28 Pain Relevance 0.30

General Comments

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