INT254812

Context Info Confidence 0.25 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.94 Pain Relevance 0.03

transport (Smad3) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)

Anatomy Link Frequency plaques 2 Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 7 56.24 cytokine 2 5.00 agonist 2 5.00 fibrosis 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 3 99.06 Atherosclerosis 35 98.70 Apoptosis 51 95.68 INFLAMMATION 7 56.24 Cardiovascular Disease 2 50.40 Death 15 5.00 Atherosclerotic Plaque 3 5.00 Fibrosis 2 5.00 Neointima 2 5.00 Coronary Heart Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The in vivo relevance of these findings was assessed in an experimental model of atherosclerosis in apolipoprotein E deficient mice: Treatment with Atorvastatin increased Smad3 phosphorylation and TRII overexpression, associated to elevated ECM deposition in the VSMCs within atheroma plaques, while apoptosis was not detected.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of Smad3 in plaques associated with atherosclerosis, apoptosis and disorder of lipid metabolism

1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597201 Disease Relevance 0.94 Pain Relevance 0.03

General Comments

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