INT254814

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.74
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
4T1 6
skin 2
MDA-MB-231 2
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 80.72 Quite High
antagonist 20 28.68 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 216 95.32 Very High Very High Very High
Apoptosis 69 93.24 High High
Aging 24 91.48 High High
Adhesions 7 89.28 High High
Targeted Disruption 8 89.20 High High
Metastasis 239 88.04 High High
Cancer 435 87.00 High High
Keloid Scars 4 84.72 Quite High
INFLAMMATION 32 80.72 Quite High
Colon Cancer 4 70.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that this might be due to Smad2 import in the nuclei as TSA not only reduces the phosphorylation level of Smad2 but also inhibits its import to the nuclei.
Positive_regulation (level) of Phosphorylation (phosphorylation) of Smad2
1) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.17 Pain Relevance 0.04
1 treatment (2 ng/ml), doxorubicin treatment (25 nM) also stimulated phosphorylation of Smad2 and Smad3 proteins in both 4T1 and MDA-MB-231 (Figure 2) cells, which was inhibited by the addition of the TGF?
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Smad2 in 4T1
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.51 Pain Relevance 0
Further investigation revealed that doxorubicin stimulated the phosphorylation of Smad2 and Smad3 in both 4T1 and MDA-MB-231 cells.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Smad2 in 4T1
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.95 Pain Relevance 0
Radiation induced Smad-2 phosphorylation in skin in vivo and in endothelial cells in vitro.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Smad-2 in skin
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2884035 Disease Relevance 0.32 Pain Relevance 0
induces a rapid activation of Smad pathway, characterized by increased phosphorylation of the regulatory Smads (Smad2/3) after 20 min, binding to Smad4 and nuclear translocation of the complex [4].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Smad2
5) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.34 Pain Relevance 0
1 treatment (2 ng/ml), doxorubicin treatment (25 nM) also stimulated phosphorylation of Smad2 and Smad3 proteins in both 4T1 and MDA-MB-231 (Figure 2) cells, which was inhibited by the addition of the TGF?
Positive_regulation (stimulated) of in MDA-MB-231 Phosphorylation (phosphorylation) of Smad2 in 4T1
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.51 Pain Relevance 0
Further investigation revealed that doxorubicin stimulated the phosphorylation of Smad2 and Smad3 in both 4T1 and MDA-MB-231 cells.
Positive_regulation (stimulated) of in MDA-MB-231 Phosphorylation (phosphorylation) of Smad2 in 4T1
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.95 Pain Relevance 0

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