INT254818

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.27
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
skin 3
lung 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 104 91.92 High High
Inflammation 55 91.08 High High
metalloproteinase 15 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 137 100.00 Very High Very High Very High
Injury 54 100.00 Very High Very High Very High
Ureteral Obstruction 36 99.98 Very High Very High Very High
Apoptosis 119 98.16 Very High Very High Very High
Stress 6 98.12 Very High Very High Very High
Atherosclerosis 72 95.96 Very High Very High Very High
INFLAMMATION 64 91.08 High High
Diphtheria 2 67.72 Quite High
Death 30 42.16 Quite Low
Sprains And Strains 6 42.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of TLR2 deficiency on UUO-induced tubular injury and ECM accumulation
Positive_regulation (induced) of Positive_regulation (accumulation) of ECM associated with ureteral obstruction and injury
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.75 Pain Relevance 0.07
In our model atorvastatin increases ECM accumulation what leads to a strengthening of the fibrous cap, while apoptosis was not detectable.
Positive_regulation (increases) of Positive_regulation (accumulation) of ECM associated with apoptosis
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.66 Pain Relevance 0.08
In our model atorvastatin increases ECM accumulation what leads to a strengthening of the fibrous cap, while apoptosis was not detectable.
Positive_regulation (leads) of Positive_regulation (accumulation) of ECM associated with apoptosis
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.66 Pain Relevance 0.08
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (expression) of Positive_regulation (induced) of ECM in skin associated with fibrosis
4) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (expression) of in lung Positive_regulation (induced) of ECM in skin associated with fibrosis
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0

General Comments

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