INT254852

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.03

transport (Smad3) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3) extracellular region (Col7a1)

Col7a1 (Mus musculus) Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 7 67.72 cytokine 2 18.64 agonist 2 5.00 fibrosis 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 35 95.96 Apoptosis 51 88.20 INFLAMMATION 7 67.72 Death 15 5.00 Atherosclerotic Plaque 3 5.00 Disorder Of Lipid Metabolism 3 5.00 Fibrosis 2 5.00 Cardiovascular Disease 2 5.00 Neointima 2 5.00 Coronary Heart Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Atorvastatin increased Smad3 phosphorylation associated to elevated PAI-1 expression, collagen deposition and SMA staining, indicating that the TGF-?

collagen Binding (associated) of Smad3

1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

This test has worked.