INT254863

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0

cytoplasm (Tgfb1, Smad3) nucleus (Tgfb1, Smad3) transport (Smad3) intracellular (Smad3) DNA binding (Smad3) enzyme binding (Tgfb1)

Tgfb1 (Mus musculus) Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 7 5.00 cytokine 2 5.00 agonist 2 5.00 fibrosis 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 51 65.48 Death 15 60.52 Clostridium Infection 1 42.68 Atherosclerosis 35 5.00 INFLAMMATION 7 5.00 Atherosclerotic Plaque 3 5.00 Disorder Of Lipid Metabolism 3 5.00 Fibrosis 2 5.00 Cardiovascular Disease 2 5.00 Neointima 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment with Y-27632, an inhibitor of the downstream RhoA mediator ROCK, enhanced Smad-dependent transcription and Smad3 phosphorylation caused by TGF-?

TGF Positive_regulation (caused) of Transcription (transcription) of Smad3

1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.