INT254873

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.24
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
neurons 1
brains 1
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 6 66.88 Quite High
medulla 2 32.20 Quite Low
Hippocampus 10 31.28 Quite Low
cerebral cortex 3 30.76 Quite Low
Clonidine 9 20.36 Low Low
Antinociceptive 1 19.12 Low Low
antinociception 1 13.08 Low Low
analgesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 68 99.64 Very High Very High Very High
Starvation 20 96.24 Very High Very High Very High
Disease 179 93.00 High High
Neurological Disease 3 67.28 Quite High
Neurodegenerative Disease 67 56.56 Quite High
Targeted Disruption 56 53.68 Quite High
Toxicity 71 50.00 Quite Low
Lewy Body Disease 6 50.00 Quite Low
Death 25 48.28 Quite Low
Weight Loss 6 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Not unexpectedly, we saw no obvious change in LC3-II levels in the brains of treated mice.
Neg (no) Regulation (change) of LC3-II in brains
1) Confidence 0.58 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.06 Pain Relevance 0
One way in which ROS may be acting to regulate autophagy is by the modulation of the action of Atg4 on Atg8/LC3.
Regulation (modulation) of LC3
2) Confidence 0.22 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.39 Pain Relevance 0
Compared to the unimpaired neurons in the control cases, in DLB brains, mTor and LC3 immunoreactivity were more abundant in neurons displaying ?
Regulation (immunoreactivity) of LC3 in neurons associated with parkinson's disease
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.71 Pain Relevance 0.03
Changes in steady-state LC3-II levels provide both a surrogate for autophagosome number and an idea as to where these effects occur in the progression of autophagy.


Regulation (Changes) of LC3-II
4) Confidence 0.13 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.08 Pain Relevance 0
(F–K) Effect of PSA modulation on LC3-II levels.
Regulation (modulation) of LC3
5) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
LC3-II levels are shown relative to actin, as a loading control in each case.
Regulation (control) of LC3
6) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0

General Comments

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