INT254874

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
fibroblasts 2
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 48.64 Quite Low
agonist 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sulfatase Deficiency Disease 9 99.84 Very High Very High Very High
Death 5 73.08 Quite High
Neurodegenerative Disease 12 72.20 Quite High
Lysosome Storage Disease 5 69.48 Quite High
Disease 45 67.12 Quite High
Tauopathy 2 27.92 Quite Low
Spinocerebellar Ataxia Type 2 1 20.24 Low Low
Frailty 1 9.68 Low Low
Muscle Disease 1 8.36 Low Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of cell lines derived from MSD mice and their wildtype littermates showed a decrease in the colocalisation of the lysosomal marker, LAMP1, and LC3 in MSD mouse embryonic fibroblasts (MEFs).
Negative_regulation (decrease) of Localization (colocalisation) of LC3 in fibroblasts associated with multiple sulfatase deficiency disease
1) Confidence 0.18 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 1.05 Pain Relevance 0

General Comments

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