INT254877

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 20
Disease Relevance 6.29
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
primary neurons 2
HeLa 2
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 79 90.88 High High
depression 5 64.96 Quite High
Enkephalin 6 59.00 Quite High
Hippocampus 18 55.68 Quite High
imagery 30 5.00 Very Low Very Low Very Low
carbamazepine 16 5.00 Very Low Very Low Very Low
analgesia 12 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
sSRI 11 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 712 99.92 Very High Very High Very High
Toxicity 182 99.80 Very High Very High Very High
Dna Damage 48 99.32 Very High Very High Very High
Cognitive Disorder 4 98.44 Very High Very High Very High
Neurodegenerative Disease 116 96.40 Very High Very High Very High
Apoptosis 121 96.16 Very High Very High Very High
Stress 65 95.12 Very High Very High Very High
Movement Disorders 6 92.28 High High
Congenital Anomalies 6 90.80 High High
Dementia 8 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Htt and DsRed was induced by 1 µg/ml doxycycline.


Positive_regulation (induced) of Gene_expression (Expression) of Htt
1) Confidence 0.64 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.09 Pain Relevance 0.04
We found that an expression level of mutant Htt almost equivalent to the expression level of endogenous Htt was sufficient for interaction with Ku70 (Fig. 3 D, bottom).
Positive_regulation (sufficient) of Gene_expression (expression) of mutant Htt
2) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Inducible expression of mutant Htt
Positive_regulation (Inducible) of Gene_expression (expression) of mutant Htt
3) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.09 Pain Relevance 0.08
We found that an expression level of mutant Htt almost equivalent to the expression level of endogenous Htt was sufficient for interaction with Ku70 (Fig. 3 D, bottom).
Positive_regulation (sufficient) of Gene_expression (expression) of Htt
4) Confidence 0.56 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
We found that an amount of mutant Htt almost equivalent to the endogenous Htt expression level was sufficient for inhibition of DNA–PK activity (Fig. 5 F).
Positive_regulation (equivalent) of Gene_expression (expression) of Htt
5) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0
This hypothesis was derived from the observation that two critical mediators of the genotoxic stress signal pathway, p53 and p73, are activated in cultured cells and mouse models expressing mutant huntingtin (Htt) protein (Steffan et al., 2000; Bae et al., 2005; Hoshino et al., 2006).
Positive_regulation (activated) of Gene_expression (expressing) of Htt associated with dna damage
6) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.72 Pain Relevance 0
This hypothesis was derived from the observation that two critical mediators of the genotoxic stress signal pathway, p53 and p73, are activated in cultured cells and mouse models expressing mutant huntingtin (Htt) protein (Steffan et al., 2000; Bae et al., 2005; Hoshino et al., 2006).
Positive_regulation (activated) of Gene_expression (expressing) of huntingtin associated with dna damage
7) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.71 Pain Relevance 0
We found that an expression level of mutant Htt almost equivalent to the expression level of endogenous Htt was sufficient for interaction with Ku70 (Fig. 3 D, bottom).
Positive_regulation (equivalent) of Gene_expression (expression) of mutant Htt
8) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
We found that an amount of mutant Htt almost equivalent to the endogenous Htt expression level was sufficient for inhibition of DNA–PK activity (Fig. 5 F).
Positive_regulation (equivalent) of Gene_expression (expression) of mutant Htt
9) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0
We found that an expression level of mutant Htt almost equivalent to the expression level of endogenous Htt was sufficient for interaction with Ku70 (Fig. 3 D, bottom).
Positive_regulation (sufficient) of Gene_expression (expression) of mutant Htt
10) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Consistently, we observed the increase of 8-oxo-dG in our primary neurons expressing mutant Htt (unpublished data).
Positive_regulation (increase) of Gene_expression (expressing) of mutant Htt in primary neurons
11) Confidence 0.38 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.82 Pain Relevance 0
We found that doxycycline-induced expression of mutant Htt directly triggered GFP-H2AX foci formation in HeLa cells (Fig. 7 A).
Positive_regulation (induced) of Gene_expression (expression) of mutant Htt in HeLa
12) Confidence 0.38 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.29 Pain Relevance 0
Interestingly, the expression of PSA was found to be highly induced in PC12 cells upon expression of huntingtin exon 1 containing an expanded, but not a normal length, polyQ sequence (22).
Positive_regulation (induced) of Gene_expression (expression) of huntingtin
13) Confidence 0.12 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.41 Pain Relevance 0.09
HD is caused by a trinucleotide expansion in the IT15 gene, coding for the mutant protein huntingtin, and has an autosomal dominant hereditary pattern.
Positive_regulation (caused) of Gene_expression (expansion) of IT15 associated with disease
14) Confidence 0.10 Published 2010 Journal Curr Treat Options Neurol Section Body Doc Link PMC2918785 Disease Relevance 1.04 Pain Relevance 0.08
Many of the proteins found here to accumulate on PSA inhibition or to be cleared faster upon PSA overexpression are autophagy substrates, including mutant huntingtin exon 1, full-length ataxin-3, mutant SOD1 and A53T ?
Positive_regulation (upon) of Gene_expression (exon) of huntingtin
15) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.05 Pain Relevance 0
However, transfection with expanded huntingtin with 41 and 74Q caused the formation of GFP-labelled inclusions in all the electroporated fibres (Fig. 3A).
Positive_regulation (transfection) of Gene_expression (transfection) of huntingtin
16) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.14 Pain Relevance 0
Small molecular inhibitors of PSA also increased aggregation of polyglutamine proteins with a range of repeat lengths. 293A cells were transfected with htt-exon-1-GFP with 23Q (D), 41Q (E) or 74Q (F).
Positive_regulation (increased) of Gene_expression (transfected) of htt-exon-1-GFP
17) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.40 Pain Relevance 0
Small molecular inhibitors of PSA also increased aggregation of polyglutamine proteins with a range of repeat lengths. 293A cells were transfected with htt-exon-1-GFP with 23Q (D), 41Q (E) or 74Q (F).
Positive_regulation (transfected) of Gene_expression (transfected) of htt-exon-1-GFP
18) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.33 Pain Relevance 0
PSA suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo
Positive_regulation (accumulation) of Gene_expression (aggregates) of huntingtin associated with toxicity
19) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.16 Pain Relevance 0
This results in an increase in the number of huntingtin aggregates in mammalian cells [67,68,71].
Positive_regulation (increase) of Gene_expression (aggregates) of huntingtin
20) Confidence 0.07 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.89 Pain Relevance 0

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