INT254878

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.32
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
fibroblasts 2
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 94.24 High High
ischemia 35 91.44 High High
addiction 2 48.00 Quite Low
Spinal cord 1 38.32 Quite Low
Inflammation 7 24.80 Low Low
Inflammatory mediators 1 7.84 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sulfatase Deficiency Disease 14 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 97.28 Very High Very High Very High
Neurodegenerative Disease 37 95.12 Very High Very High Very High
Parkinson's Disease 68 93.16 High High
Cv Unclassified Under Development 22 91.44 High High
Disease 121 90.64 High High
Death 16 83.08 Quite High
Middle Cerebral Artery Infarction 5 79.92 Quite High
Mucopolysaccharidoses 1 79.92 Quite High
Pompes Disease 1 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-syn aggregates that co-localize with abnormally enlarged LC3-positive structures [42].
Localization (localize) of LC3
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.53 Pain Relevance 0
In the present study, we examined whether Rab33B colocalized with LC3 of autophagy marker.
Spec (whether) Localization (colocalized) of LC3
2) Confidence 0.37 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC3002892 Disease Relevance 0.54 Pain Relevance 0.20
Analysis of cell lines derived from MSD mice and their wildtype littermates showed a decrease in the colocalisation of the lysosomal marker, LAMP1, and LC3 in MSD mouse embryonic fibroblasts (MEFs).
Localization (colocalisation) of LC3 in fibroblasts associated with multiple sulfatase deficiency disease
3) Confidence 0.31 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 1.05 Pain Relevance 0
Analysis of the cell lines derived from MSD mice and their wild-type littermates show a decrease in the colocalization of the lysosomal marker, LAMP-1, and LC3 in MSD mouse embryonic fibroblasts (MEFs) [40,47], and the accumulation of autophagosomes resulting from impaired fusion of autophagosomes with lysosomes.
Localization (colocalization) of LC3 in fibroblasts associated with multiple sulfatase deficiency disease
4) Confidence 0.22 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.01 Pain Relevance 0
The autophagic marker LC3-II co-localized with the H. pylori-containing vacuole at 2 h p.i.
Localization (localized) of LC3-II
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.18 Pain Relevance 0

General Comments

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