INT254881

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.69
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7)
cytoplasm (Atg7)
Anatomy Link Frequency
brains 2
hippocampus 1
temporal cortex 1
Atg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 35 97.40 Very High Very High Very High
Pyramidal cell 42 79.44 Quite High
Neurobehavioral 7 42.08 Quite Low
imagery 7 21.96 Low Low
Limbic system 21 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Locus ceruleus 7 5.00 Very Low Very Low Very Low
Substantia nigra 7 5.00 Very Low Very Low Very Low
Immobilon 7 5.00 Very Low Very Low Very Low
Clonidine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 89 100.00 Very High Very High Very High
Parkinson's Disease 416 99.84 Very High Very High Very High
Disease 450 98.96 Very High Very High Very High
Neurodegenerative Disease 86 98.72 Very High Very High Very High
Stress 3 96.96 Very High Very High Very High
Death 27 95.56 Very High Very High Very High
Starvation 18 95.56 Very High Very High Very High
Dementia 65 89.32 High High
Pick Disease Of The Brain 21 81.08 Quite High
Neurological Disease 7 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DLB cases, levels of Atg7 were moderately reduced compared to controls and AD cases (Figure 1A, D).
Negative_regulation (reduced) of Atg7 associated with parkinson's disease and disease
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0
The mechanisms through which levels of mTor might be upregulated and Atg7 downregulated in DLB and ?
Negative_regulation (downregulated) of Atg7 associated with parkinson's disease
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.83 Pain Relevance 0
We found that levels of mTor were increased and Atg7 levels were reduced in the brains of patients with DLB and a-syn tg mice.
Negative_regulation (reduced) of Atg7 in brains associated with parkinson's disease
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.23 Pain Relevance 0
Moreover, levels of a molecular initiator of autophagy, Atg7, were reduced in ?
Negative_regulation (reduced) of Atg7
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.34 Pain Relevance 0.07
For this purpose, we delivered the Atg7 lentivirus via stereotaxic injection to the temporal cortex and hippocampus of non tg and ?
Negative_regulation (delivered) of Atg7 in hippocampus associated with hippocampus
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.36 Pain Relevance 0.13
Recent studies have shown that constitutive autophagy may play a pivotal role in the clearance of normally occurring cellular misfolded proteins, as loss of basal autophagy by conditional knock-out of key autophagy genes, such as Atg5 and Atg7, in mouse brains resulted in a neurodegenerative phenotype and the formation of protein aggregates (14, 15).
Negative_regulation (loss) of Atg7 in brains associated with targeted disruption and neurodegenerative disease
6) Confidence 0.22 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.28 Pain Relevance 0
Increased lethality and a decrease in GFP-LC3 levels in Atg7 deficient flies indicated that autophagy deficiency was deleterious during stress-inducing conditions such as starvation, oxidative stress and metamorphosis.
Negative_regulation (decrease) of Atg7 associated with stress and starvation
7) Confidence 0.20 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.54 Pain Relevance 0
This study supports the notion that defects in the autophagy pathway and more specifically in mTor and Atg7 are associated with neurodegeneration in DLB cases and ?
Negative_regulation (defects) of Atg7 associated with parkinson's disease
8) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 0.98 Pain Relevance 0
For this purpose, we delivered the Atg7 lentivirus via stereotaxic injection to the temporal cortex and hippocampus of non tg and ?
Negative_regulation (delivered) of Atg7 in temporal cortex associated with hippocampus
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.36 Pain Relevance 0.13

General Comments

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