INT254882

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Lamp1) plasma membrane (Lamp1) lysosome (Lamp1)
Anatomy Link Frequency
fibroblasts 2
C8-B4 1
Lamp1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 48.00 Quite Low
antagonist 14 34.36 Quite Low
antidepressant 70 24.72 Low Low
Potency 8 23.12 Low Low
Neuropathic pain 18 20.88 Low Low
Endep 32 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
Desipramine 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sulfatase Deficiency Disease 14 99.48 Very High Very High Very High
Death 9 83.08 Quite High
Neurodegenerative Disease 28 82.20 Quite High
Disease 60 80.56 Quite High
Mucopolysaccharidoses 1 79.92 Quite High
Pompes Disease 1 71.28 Quite High
Lysosome Storage Disease 5 68.84 Quite High
Danon Disease 1 61.68 Quite High
Lysosomal Storage Diseases 3 59.80 Quite High
Tauopathy 3 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accord, P2X4 colocalized with the lysosomal marker LAMP1, confirming that native P2X4 receptors within resting C8-B4 cells are targeted to this intracellular organelle.
Localization (colocalized) of LAMP1 in C8-B4
1) Confidence 0.43 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
We analyzed the colocalization between P2X4 and LAMP1 using dual-color confocal microscopy and assessed the degree of colocalization using the Pearson’s correlation coefficient (r; see Data analysis in Materials and methods).
Spec (analyzed) Localization (colocalization) of LAMP1
2) Confidence 0.40 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Analysis of cell lines derived from MSD mice and their wildtype littermates showed a decrease in the colocalisation of the lysosomal marker, LAMP1, and LC3 in MSD mouse embryonic fibroblasts (MEFs).
Localization (colocalisation) of LAMP1 in fibroblasts associated with multiple sulfatase deficiency disease
3) Confidence 0.35 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 1.04 Pain Relevance 0
Analysis of the cell lines derived from MSD mice and their wild-type littermates show a decrease in the colocalization of the lysosomal marker, LAMP-1, and LC3 in MSD mouse embryonic fibroblasts (MEFs) [40,47], and the accumulation of autophagosomes resulting from impaired fusion of autophagosomes with lysosomes.
Localization (colocalization) of LAMP-1 in fibroblasts associated with multiple sulfatase deficiency disease
4) Confidence 0.14 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.01 Pain Relevance 0

General Comments

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