INT25492

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.44
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
plasma 2
EPI 2
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 4 95.52 Very High Very High Very High
Neuropeptide 6 94.96 High High
Inflammation 2 91.44 High High
local anesthetic 1 88.48 High High
Enkephalin 3 87.68 High High
Catecholamine 3 83.48 Quite High
Somatostatin 1 68.68 Quite High
cINOD 1 64.68 Quite High
anesthesia 2 62.40 Quite High
halothane 1 61.96 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 8 99.96 Very High Very High Very High
Stress 4 96.64 Very High Very High Very High
INFLAMMATION 3 91.44 High High
Disease 2 89.72 High High
Pressure Volume 2 Under Development 1 88.52 High High
Ganglion Cysts 3 86.88 High High
Heart Rate Under Development 1 64.56 Quite High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that high physiological concentrations of Epi can enhance Ra in exercising humans, but normally Epi is not a major stimulus.
Positive_regulation (enhance) of Positive_regulation (concentrations) of Epi associated with rheumatoid arthritis
1) Confidence 0.50 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368297 Disease Relevance 0.79 Pain Relevance 0.13
The present study evaluated the hypothesis that increased plasma levels of epinephrine (EPI) stimulate immunoreactive beta-endorphin (i beta END) secretion in humans experiencing a mild stress.
Positive_regulation (stimulate) of Positive_regulation (increased) of EPI in plasma associated with stress
2) Confidence 0.40 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.24 Pain Relevance 0.09
Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells.
Positive_regulation (induced) of Positive_regulation (activation) of tissue factor gene
3) Confidence 0.23 Published 1995 Journal Blood Section Title Doc Link 7492771 Disease Relevance 0.32 Pain Relevance 0.15
Splanchnic nerve stimulation at 5 Hz caused a preferential increase in adrenal vein NE (9-fold) versus EPI (7-fold) levels as compared to baseline, while 50 Hz stimulation led to further comparable increases in NE (5-fold) and EPI (6-fold) levels.
Positive_regulation (led) of Positive_regulation (increases) of EPI in EPI
4) Confidence 0.03 Published 1989 Journal Peptides Section Abstract Doc Link 2780418 Disease Relevance 0.09 Pain Relevance 0.80

General Comments

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