INT254924

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ2) transmembrane transport (KCNQ2)
KCNQ2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 24 68.56 Quite High
sodium channel 18 13.72 Low Low
Pain 2 5.44 Low Low
Spinal cord 8 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
unmyelinated 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Axonal channel 2 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 8 81.92 Quite High
Targeted Disruption 4 14.40 Low Low
Adhesions 4 14.32 Low Low
Syndrome 2 5.84 Low Low
Pain 2 5.44 Low Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Myoclonus 2 5.00 Very Low Very Low Very Low
Isaacs Syndrome 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, signals for clustering KCNQ channels appeared considerably later than in NaV channels, after sequential gene duplications that first yielded KCNQ4 and KCNQ5, then the inferred common ancestor gene, KCNQ2/3.
Negative_regulation (yielded) of Gene_expression (/) of KCNQ2
1) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03
Why do all mammalian NaV channels possess anchor motifs, but only KCNQ2 and KCNQ3 among the five KCNQ subunits?
Negative_regulation (Why) of Gene_expression (possess) of KCNQ2
2) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0.16 Pain Relevance 0

General Comments

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