INT25493

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 74
Total Number 80
Disease Relevance 39.44
Pain Relevance 14.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 22
plasma 5
chest 2
right coronary artery 2
peritoneal fluid 2
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 149 100.00 Very High Very High Very High
imagery 40 100.00 Very High Very High Very High
epidural 16 100.00 Very High Very High Very High
tetrodotoxin 3 100.00 Very High Very High Very High
aspirin 46 99.76 Very High Very High Very High
Chronic pancreatitis 1 99.76 Very High Very High Very High
analgesia 17 99.56 Very High Very High Very High
spinal inflammation 14 99.28 Very High Very High Very High
Catecholamine 156 99.16 Very High Very High Very High
Inflammation 342 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Immunization 64 100.00 Very High Very High Very High
Adhesions 54 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 100.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 5 100.00 Very High Very High Very High
Acute Coronary Syndrome 15 99.84 Very High Very High Very High
Pancreatitis 1 99.76 Very High Very High Very High
Cancer 18 99.58 Very High Very High Very High
Disorder Of Lipid Metabolism 123 99.52 Very High Very High Very High
Temporomandibular Joint Syndrome 6 99.30 Very High Very High Very High
Low Back Pain 16 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma TF and free TFPI antigen levels were higher in the unstable angina group than in the stable exertional angina and chest pain syndrome group.
Gene_expression (levels) of TFPI in chest
1) Confidence 0.76 Published 1999 Journal Circulation Section Body Doc Link 10359735 Disease Relevance 0.09 Pain Relevance 0
Epi-lipoxins (epi-LXs), for instance, are produced from aspirin's acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators.
Gene_expression (produced) of Epi associated with aspirin and cox2
2) Confidence 0.75 Published 2006 Journal ScientificWorldJournal Section Abstract Doc Link 16951898 Disease Relevance 0.64 Pain Relevance 0.80
Epi-lipoxins (epi-LXs), for instance, are produced from aspirin's acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators.
Gene_expression (produced) of epi associated with aspirin and cox2
3) Confidence 0.75 Published 2006 Journal ScientificWorldJournal Section Abstract Doc Link 16951898 Disease Relevance 0.63 Pain Relevance 0.79
The details of the anatomical structures of the TMJ were unidentifiable in the images produced with EPI and SSFSE, but were identifiable on the SSFP images.
Gene_expression (produced) of EPI in EPI associated with temporomandibular joint syndrome and imagery
4) Confidence 0.66 Published 2006 Journal Bull. Tokyo Dent. Coll. Section Abstract Doc Link 16924153 Disease Relevance 0.48 Pain Relevance 0.44
CONCLUSIONS: We have demonstrated that not only the plasma TF levels but also the plasma-free TFPI levels are elevated in patients with unstable angina.
Gene_expression (levels) of TFPI in plasma
5) Confidence 0.66 Published 1999 Journal Circulation Section Body Doc Link 10359735 Disease Relevance 0 Pain Relevance 0
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Gene_expression (levels) of TFPI associated with diabetes mellitus
6) Confidence 0.60 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.20 Pain Relevance 0.04
METHODS AND RESULTS: The plasma TF and free TFPI antigen levels were determined in plasma samples taken from 51 patients with unstable angina, 56 with stable exertional angina, and 55 with chest pain syndrome.
Gene_expression (levels) of TFPI in chest
7) Confidence 0.59 Published 1999 Journal Circulation Section Body Doc Link 10359735 Disease Relevance 0.09 Pain Relevance 0
Although the component(s) of the plant extract responsible for the antivenom activity observed in the present study has not yet been identified to verify the complete absence or present of tannins, particularly low molecular weight polyphenolic (epi-gallocatechin, epi-catechin etc.) and a long-chain ester of transferulic acid, we presume that it is unlikely that the antivenom activity is due to polyphenolic components.
Gene_expression (present) of epi
8) Confidence 0.58 Published 2010 Journal Journal of Toxicology Section Body Doc Link PMC2902021 Disease Relevance 0.07 Pain Relevance 0
Epinephrine (Epi) was in some experiments infused during blockade to match (normal Epi) or exceed (high Epi) Epi levels during Co.
Gene_expression (levels) of Epi
9) Confidence 0.58 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368297 Disease Relevance 0.53 Pain Relevance 0.19
Epinephrine (Epi) was in some experiments infused during blockade to match (normal Epi) or exceed (high Epi) Epi levels during Co.
Gene_expression (infused) of Epi
10) Confidence 0.58 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368297 Disease Relevance 0.53 Pain Relevance 0.19
Hence, the increase in the proportion of deliveries within health facilities will also lead to a better effective coverage of the EPI.
Gene_expression (coverage) of EPI in EPI associated with immunization
11) Confidence 0.54 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2405792 Disease Relevance 0.43 Pain Relevance 0
Whereas there was no association between plasma levels of EPI and i beta END in the EPI group (r = 0.119; P = NS), EPI and i beta END levels were strongly related in the no EPI group (r = 0.82; P less than 0.001).
Gene_expression (levels) of EPI in EPI
12) Confidence 0.51 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.30 Pain Relevance 0.07
The plasma levels of vWF, PAI-1, tPA, f-TFPI, and s-TM were measured using commercially available enzyme-linked immunosorbent assays (Diagnostica Stago, Asnières, France).


Gene_expression (levels) of TFPI in plasma
13) Confidence 0.46 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.42 Pain Relevance 0.09
A 10-mL blood sample was first collected in a prechilled sodium citrate-coated tube for determining circulating levels of PAI-1, vWF, tPA, f-TFPI, and s-TM.
Spec (determining) Gene_expression (levels) of TFPI in tube
14) Confidence 0.46 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.43 Pain Relevance 0.04
As a final and practical note, the apparent progression seen in our data from normal plasma levels of vWF, f-TFPI and s-TM as well as a normal PWV in diabetics without vascular or renal complications, to generalized abnormalities of these parameters when such complications are detected, suggests that the serial measurement of some, or possibly all, of these parameters might be useful for the long term monitoring of these patients.
Gene_expression (levels) of TFPI in plasma associated with congenital anomalies and diabetes mellitus
15) Confidence 0.40 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.64 Pain Relevance 0
The median levels of total TFPI, free TFPI, FVIIc and prothrombin fragments 1+2 were higher in hyperlipidemic patients than healthy subjects.
Gene_expression (levels) of TFPI
16) Confidence 0.40 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.46 Pain Relevance 0.38
TF proteolytic activity was measured with spectrozyme factor Xa (FXa), TF and TFPI-1 surface expression on monocytes by flow cytometry, RNA expression in whole blood by reverse transcription-polymerase chain reaction, and concentrations of plasma prothrombin fragments F(1 + 2) by immunoassay.
Gene_expression (expression) of TFPI-1 in plasma
17) Confidence 0.37 Published 2001 Journal Blood Section Abstract Doc Link 11389008 Disease Relevance 0.72 Pain Relevance 0.10
The median levels of total TFPI, free TFPI, FVIIc and prothrombin fragments 1+2 were higher in hyperlipidemic patients than healthy subjects.
Gene_expression (levels) of TFPI
18) Confidence 0.35 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.45 Pain Relevance 0.38
We developed an implantable infusion pump, allowing to accommodate large volumes (16-50mL) of high viscous solutions (up to 23.96mPas at 39 degrees C) of anti-HIV agents and providing sustained release of medication: a standard Codman 3000 pump, which was initially developed to release aqueous solutions ( approximately 0.7mPas) into the spinal cord such as for pain medication, was transformed for release of viscous solutions up to 40mPas by adapting the diameter of the capillary flow restrictor, the capillary length and way of catheterisation--by placing the indwelling catheter in the vena cava.
Gene_expression (agents) of anti-HIV in vena cava associated with pain, acquired immune deficiency syndrome or hiv infection and spinal cord
19) Confidence 0.34 Published 2008 Journal Int J Pharm Section Abstract Doc Link 18337029 Disease Relevance 0.62 Pain Relevance 0.18
Maximal levels of tissue factor pathway inhibitor (TFPI) were observed at the beginning of CPB.
Gene_expression (beginning) of TFPI
20) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2206501 Disease Relevance 0.42 Pain Relevance 0.12

General Comments

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