INT254930

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.01
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CELSR3) plasma membrane (CELSR3) signal transducer activity (CELSR3)
Anatomy Link Frequency
stellate cells 1
CELSR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 88 97.16 Very High Very High Very High
metalloproteinase 2 81.00 Quite High
addiction 2 70.20 Quite High
Chronic pancreatitis 36 56.72 Quite High
Bile 4 22.88 Low Low
Action potential 24 5.00 Very Low Very Low Very Low
sodium channel 18 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 60 99.80 Very High Very High Very High
Cancer 186 98.52 Very High Very High Very High
INFLAMMATION 89 97.16 Very High Very High Very High
Primary Sclerosing Cholangitis 124 93.20 High High
Pancreatic Cancer 44 92.56 High High
Adenocarcinoma 48 89.92 High High
Chronic Myeloid Leukemia 4 83.96 Quite High
Leukemia 4 82.72 Quite High
Myelodysplastic Syndromes 4 82.64 Quite High
Myeloproliferative Disorder 4 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also a disease specific expression of CELSR3 expression in tissues (Figure 9C-F).
Gene_expression (expression) of CELSR3 associated with disease
1) Confidence 0.76 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.28 Pain Relevance 0.20
By immunoblot analysis, CELSR3 protein was expressed at 83% higher levels (p = 0.030) in tumor related stellate cells compared to that of inflammation related stellate cells (Figure 9B).
Gene_expression (expressed) of CELSR3 protein in stellate cells associated with inflammation and cancer
2) Confidence 0.76 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.30 Pain Relevance 0.19
CELSR3 is a member of the flamingo protein subfamily which is part of the cadherin superfamily.
Gene_expression (member) of CELSR3
3) Confidence 0.66 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.07 Pain Relevance 0.06
The KCNQ2/3 Anchor Is a Shared Feature of Extant Jawed Vertebrates
Gene_expression (/) of Anchor
4) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03
The KCNQ2/3 Anchor Is a Shared Feature of Extant Jawed Vertebrates
Gene_expression (The) of Anchor
5) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.04
There was also a disease specific expression of CELSR3 expression in tissues (Figure 9C-F).
Gene_expression (expression) of CELSR3 associated with disease
6) Confidence 0.59 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.28 Pain Relevance 0.20
Fujita and colleagues [22] used rat NP to identify cell surface markers that were specific to NP cells and identified CD24, a glycosylphosphatidylinositol anchor protein, as being highly expressed in NP cells in a tissue specific manner.
Gene_expression (expressed) of anchor protein
7) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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