INT25499

Context Info Confidence 0.52 First Reported 1984 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 14 Total Number 15 Disease Relevance 5.31 Pain Relevance 1.70

lipid binding (DBI) transport (DBI)

Anatomy Link Frequency plasma 2 pituitary gland 1 DBI (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 7 100.00 Clonidine 8 99.82 analgesia 2 97.88 opiate 2 97.48 Analgesic 4 92.44 abdominal pain 4 83.20 Endogenous opioid 2 75.00 Enkephalin 2 75.00 antagonist 2 75.00 pain pelvic 4 37.52

Disease Link Frequency Relevance Heat Ectopic Pregnancy 190 100.00 Hypoglycemia 12 99.52 Tubal Pregnancy 20 98.90 Threatened Abortion 2 97.64 Obesity 30 97.18 Disease 4 95.12 Reprotox - General 1 28 85.12 Spontaneous Abortion 10 84.48 Abdominal Pain 4 83.20 Rupture 6 66.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In normal prepubertal subjects, the circadian rhythms of beta EP and beta LPH secretion and release induced by hypoglycemia suggest the presence of a well developed neuroendocrine control of proopiomelanocortin-related peptide secretion.

Localization (release) of EP associated with hypoglycemia

1) Confidence 0.52 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 1.09 Pain Relevance 0.06

In obese adolescents, in spite of the normal rhythm of beta LPH and cortisol, beta EP levels did not change throughout the day, thus suggesting beta EP secretion from nonpituitary sources in these subjects.

Localization (secretion) of EP associated with obesity

2) Confidence 0.52 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 0.75 Pain Relevance 0

In normal prepubertal subjects, the circadian rhythms of beta EP and beta LPH secretion and release induced by hypoglycemia suggest the presence of a well developed neuroendocrine control of proopiomelanocortin-related peptide secretion.

Localization (secretion) of EP associated with hypoglycemia

3) Confidence 0.52 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 1.09 Pain Relevance 0.06

These results suggest that beta-EP is preferentially released in response to acute corticotrophin releasing hormone stimulation.

Localization (released) of beta-EP

4) Confidence 0.46 Published 1993 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 8287571 Disease Relevance 0 Pain Relevance 0

To stimulate beta-EP release, ovine corticotropin-releasing factor (oCRF) and arginine vasopressin (AVP) were injected intravenously (iv) into a group of 12 out of 24 sheep, 15 min prior to minor surgery on all sheep.

Localization (release) of beta-EP

5) Confidence 0.46 Published 1989 Journal Life Sci. Section Abstract Doc Link 2527327 Disease Relevance 0 Pain Relevance 0.09

Ultrafiltration indicated that less than 30% of the released beta-EP immunoreactivity was present as higher molecular weight forms (mol. wt greater than 10,000) and that the majority (about 75%) of the beta-EP was probably bound to plasma proteins.

Localization (released) of beta-EP in plasma

6) Confidence 0.40 Published 1989 Journal Life Sci. Section Abstract Doc Link 2527327 Disease Relevance 0 Pain Relevance 0.07

These data suggest that the existence of sex differences for beta-EP secretion and release, and opioid peptides secretion and release mechanism might change with sexual maturation, due to changing sex steroids secretion.

Localization (secretion) of beta-EP associated with opioid

7) Confidence 0.22 Published 1984 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6323285 Disease Relevance 0 Pain Relevance 0.10

These data suggest that the existence of sex differences for beta-EP secretion and release, and opioid peptides secretion and release mechanism might change with sexual maturation, due to changing sex steroids secretion.

Localization (secretion) of beta-EP associated with opioid

8) Confidence 0.22 Published 1984 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6323285 Disease Relevance 0 Pain Relevance 0.10

The authors concluded that VEGF serum concentrations might be a useful marker for differentiating between EP and abnormal IUP, and suggested 174 pg/ml as the cut-off value for EP diagnosis.12

Localization (value) of EP associated with ectopic pregnancy

9) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.82 Pain Relevance 0

No significant difference was observed in the median CK values associated with normal pregnancies or threatened abortion when compared to asymptomatic or symptomatic tubal pregnancies, suggesting that serum CK is not a useful biochemical marker for EP diagnosis.43

Localization (marker) of EP associated with tubal pregnancy, threatened abortion and ectopic pregnancy

10) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.25 Pain Relevance 0.08

Clonidine-induced release of plasma beta-EP may be of importance with regard to its therapeutic effects in detoxification.

Localization (release) of beta-EP in plasma associated with clonidine

11) Confidence 0.11 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857510 Disease Relevance 0 Pain Relevance 0.34

In the controls, clonidine induced release of beta-LPH and beta-EP after 30 min (from 8.9 +/- 1.0 to 19.1 +/- 4.6 fmol/ml, P less than 0.01 and from 8.1 +/- 0.6 to 17.9 +/- 4.6, P less than 0.01) and of ACTH after 60 min (from 12.1 +/- 1.8 to 18.1 +/- 1.8, P less than 0.05) while in addicts beta-EP but not beta-LPH showed a significant increase (from 8.5 +/- 0.7 to 19.8 +/- 4.2, P less than 0.05), 90 min after the injection.

Localization (release) of beta-EP associated with clonidine

12) Confidence 0.11 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857510 Disease Relevance 0 Pain Relevance 0.24

It inhibited beta-EP-induced GH release in a dose-related way but left beta-EP-induced PRL stimulation unchanged.

Localization (release) of beta-EP

13) Confidence 0.08 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2946593 Disease Relevance 0 Pain Relevance 0.21

We have evaluated the effects of the fragment on h beta-EP-induced growth hormone (GH) and prolactin (PRL) release.

Localization (release) of beta-EP

14) Confidence 0.08 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2946593 Disease Relevance 0 Pain Relevance 0.21

These results support the theory that Nt, Ep, LPH and ACTH are produced simultaneously from POMC as a common precursor in the pituitary gland and are secreted concomitantly under various conditions such as stimulation by CRF and inhibition by FK 33-824 in patients with Addison's disease.

Localization (secreted) of Ep in pituitary gland associated with disease

15) Confidence 0.02 Published 1986 Journal Endocrinol. Jpn. Section Abstract Doc Link 3034555 Disease Relevance 0.31 Pain Relevance 0.14

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