INT255014

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.81
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F10) extracellular region (F10) plasma membrane (F10)
Anatomy Link Frequency
plasma 8
F10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 22 91.88 High High
cva 156 62.76 Quite High
Parenteral administration 1 23.68 Low Low
antagonist 31 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
epidural 6 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 7 93.04 High High
Hemorrhage 81 87.92 High High
Thrombosis Related Under Development 60 80.96 Quite High
Thrombosis 66 74.72 Quite High
Syndrome 8 71.28 Quite High
Cv General 3 Under Development 83 62.76 Quite High
Pulmonary Embolism 38 5.00 Very Low Very Low Very Low
Body Weight 32 5.00 Very Low Very Low Very Low
Stroke 32 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike heparin, fondaparinux does not inactivate thrombin or inhibit FXa bound in the prothrombinase complex and therefore does not completely inhibit FXa.
Negative_regulation (inhibit) of FXa Binding (bound) of
1) Confidence 0.34 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.94 Pain Relevance 0.03
In vitro studies have shown that rivaroxaban can inhibit both free FXa and FXa bound in the prothrombinase complex more potently in human and rabbit plasma than in rat plasma.
Negative_regulation (inhibit) of FXa Binding (bound) of in plasma
2) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.22 Pain Relevance 0.05
As a consequence the direct FXa inhibitors are able to inhibit both free FXa and FXa bound in the prothrombinase complex (Perzborn 2005) (Figure 1).
Negative_regulation (inhibit) of FXa Binding (bound) of
3) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0 Pain Relevance 0.03
In vitro studies have shown that rivaroxaban can inhibit both free FXa and FXa bound in the prothrombinase complex more potently in human and rabbit plasma than in rat plasma.
Negative_regulation (inhibit) of FXa Binding (free) of in plasma
4) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.22 Pain Relevance 0.05
As a consequence the direct FXa inhibitors are able to inhibit both free FXa and FXa bound in the prothrombinase complex (Perzborn 2005) (Figure 1).
Negative_regulation (inhibit) of FXa Binding (bound) of
5) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0 Pain Relevance 0.03
In vitro studies have shown that rivaroxaban can inhibit both free FXa and FXa bound in the prothrombinase complex more potently in human and rabbit plasma than in rat plasma.
Negative_regulation (inhibit) of FXa Binding (free) of in plasma
6) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.22 Pain Relevance 0.05
In vitro studies have shown that rivaroxaban can inhibit both free FXa and FXa bound in the prothrombinase complex more potently in human and rabbit plasma than in rat plasma.
Negative_regulation (inhibit) of FXa Binding (bound) of in plasma
7) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.22 Pain Relevance 0.05

General Comments

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