INT255017

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Got2) mitochondrion (Got2) biosynthetic process (Got2)
plasma membrane (Got2) enzyme binding (Got2) protein complex (Got2)
Anatomy Link Frequency
liver 1
beta cells 1
Got2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 32 50.00 Quite Low
Bioavailability 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
epidural 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 2 94.88 High High
Hemorrhage 18 91.40 High High
Thrombosis Related Under Development 4 50.00 Quite Low
Cholecystolithiasis 2 35.84 Quite Low
Cv General 3 Under Development 20 8.64 Low Low
Thrombosis 14 5.00 Very Low Very Low Very Low
Pulmonary Embolism 10 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To follow the liver function repeated measurements of liver aminotransferase levels such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin levels up to 7 days after the last dose of study medication were performed.
Gene_expression (levels) of AST in liver
1) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.19 Pain Relevance 0
In the phase II TKA study (Turpie et al 2005), elevated levels of ALT and AST (>3x ULN) and of bilirubin (2x ULN) were seen in 4 patients in the rivaroxaban groups.
Gene_expression (levels) of AST
2) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.15 Pain Relevance 0
Despite their 2 fold higher glucose oxidation rate ([16], [20] and Fig. 5c), highly responsive beta cells show no major difference in expression of the mitochondrial branch of the NADH shuttle (Got2 and Mdh2), various TCA cycle enzymes (Mdh2, Idh2, Aco2) or even the anaplerotic enzyme pyruvate carboxylase (Pc) (Fig. 5a).
Gene_expression (expression) of Got2 in beta cells
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0

General Comments

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