INT25503

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 21.88
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
endothelial cells 4
neutrophil 3
plasma 2
cleavage 2
eosinophils 2
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 154 100.00 Very High Very High Very High
cINOD 8 100.00 Very High Very High Very High
Hyperalgesia 10 99.98 Very High Very High Very High
bradykinin 8 99.92 Very High Very High Very High
Central nervous system 7 99.16 Very High Very High Very High
Analgesic 2 98.82 Very High Very High Very High
pruritus 8 98.46 Very High Very High Very High
antagonist 84 97.38 Very High Very High Very High
Pain 8 96.40 Very High Very High Very High
rheumatoid arthritis 28 93.84 High High
Disease Link Frequency Relevance Heat
Dengue 624 100.00 Very High Very High Very High
INFLAMMATION 209 100.00 Very High Very High Very High
Hyperalgesia 10 99.98 Very High Very High Very High
Eosinophilia 6 99.72 Very High Very High Very High
Atherosclerosis 156 99.60 Very High Very High Very High
Syndrome 11 99.54 Very High Very High Very High
Flavivirus Infection 480 99.52 Very High Very High Very High
Pressure And Volume Under Development 6 99.02 Very High Very High Very High
Thrombocytopenia 48 99.00 Very High Very High Very High
Pruritus 8 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation that levels of C3 were directly correlated with the platelet levels and inversely correlated with C3a and C5a levels (Table 3) is consistent with previous reports that C3 consumption and C3a and C5a production are correlated with the thrombocytopenia seen in people developing the most severe form of the disease [43], [44].
Gene_expression (production) of C5a in platelet associated with thrombocytopenia and disease
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.97 Pain Relevance 0
A case of episodic angioedema associated with blood eosinophilia: upregulated C5a receptor expression on eosinophils.
Gene_expression (expression) of C5a in eosinophils associated with pressure and volume under development and eosinophilia
2) Confidence 0.75 Published 1998 Journal Allergy Section Title Doc Link 9542615 Disease Relevance 0.74 Pain Relevance 0.10
Quantitation of C5a receptor (C5aR) expression by flow cytometry using anti-C5aR antibody showed upregulated expression of C5aR on blood eosinophils but downregulated expression on neutrophils.
Gene_expression (expression) of C5a in eosinophils
3) Confidence 0.75 Published 1998 Journal Allergy Section Abstract Doc Link 9542615 Disease Relevance 0.66 Pain Relevance 0.08
In addition, clinical studies have shown that the levels of dengue NS1 and products of complement activation, including those with a known vascular effect, such as C3a, C5a, and sC5b-9, are present in higher levels in DHF patients before plasma leakage takes place, supporting the theory that complement activation is involved in the development of severe disease [12] and to deleterious patient outcomes [11], [13], [14].
Gene_expression (levels) of C5a in plasma associated with flavivirus infection, dengue and disease
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.03 Pain Relevance 0
A recent study shows that C3AR1 and C5R1 are expressed in human atherosclerotic coronary plaques [38].
Gene_expression (expressed) of C5R1 in plaques associated with atherosclerosis
5) Confidence 0.68 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.20 Pain Relevance 0.04
Double immunofluorescence staining has shown that the plaque of cells that express both C3aR and C5aR are macrophages, T cells, endothelial cells, and sub-endothelial smooth muscle cells.
Gene_expression (express) of C5aR in T cells
6) Confidence 0.68 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.17 Pain Relevance 0.04
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Gene_expression (production) of C5a associated with flavivirus infection
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.96 Pain Relevance 0
We also measured the plasma levels of C3a, a product of C3 cleavage, and C5a, a product of C5 cleavage, in samples from patients with confirmed dengue infection and different clinical diagnoses (Figure 2).
Gene_expression (product) of C5a in cleavage associated with dengue and infection
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.73 Pain Relevance 0
The disappearance of 9-H in the 1H NMR spectra and the appearance of C-5a in the 13C NMR spectra as an azomethine carbon signal at ?
Gene_expression (appearance) of C-5a
9) Confidence 0.65 Published 2007 Journal Beilstein J Org Chem Section Body Doc Link PMC1847824 Disease Relevance 0 Pain Relevance 0
Various aspects of this syndrome, such as its clinical features, the cell types and mediators involved, the role of underlying chronic inflammatory processes, the patterns of cross-reactivity between NSAIDs, the major role of sulfidoleukotrienes (LTC4) and of some other mediators such as prostaglandin E2 (PGE2) and C5a are briefly reviewed.
Gene_expression (features) of C5a associated with inflammation, syndrome and cinod
10) Confidence 0.65 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17017929 Disease Relevance 1.16 Pain Relevance 0.62
In vivo studies have shown that human C5a, a potent complement-derived anaphylatoxin and chemoattractant, produces immediate inflammatory reactions following intradermal injection in human skin.
Gene_expression (produces) of C5a in skin associated with inflammation
11) Confidence 0.65 Published 1987 Journal J. Invest. Dermatol. Section Abstract Doc Link 3559264 Disease Relevance 0.34 Pain Relevance 0.08
Thus, the hyperalgesia produced by fMLP and C5a is similar to that produced by leukotriene B4 in that it is dependent on PMNLs and independent of the cyclo-oxygenation of arachidonic acid.
Gene_expression (produced) of C5a associated with hyperalgesia
12) Confidence 0.65 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2997412 Disease Relevance 0.84 Pain Relevance 0.94
We also measured the plasma levels of C3a, a product of C3 cleavage, and C5a, a product of C5 cleavage, in samples from patients with confirmed dengue infection and different clinical diagnoses (Figure 2).
Gene_expression (levels) of C5a in cleavage associated with dengue and infection
13) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.80 Pain Relevance 0
DHF patients have elevated levels of the anaphylotoxins C3a and C5a
Gene_expression (levels) of C5a associated with flavivirus infection
14) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.75 Pain Relevance 0
C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection.
Gene_expression (product) of C5a associated with inflammation
15) Confidence 0.58 Published 1989 Journal J. Invest. Dermatol. Section Abstract Doc Link 2527912 Disease Relevance 0.31 Pain Relevance 0.11
DSM491 expresses sodB with the C-5A mutation from its native locus within the G27 chromosome.


Gene_expression (expresses) of C-5A
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.32 Pain Relevance 0
The causes of pruritus in patients undergoing hemodialysis and the mechanism of the antipruritic effect of Neurotropin, an extract isolated from the inflamed dermis of rabbits inoculated with vaccinia virus and clinically used in Japan as an analgesic and antiallergic drug, were investigated by measuring the levels of C3a, C5a, bradykinin and lipid peroxides in venous blood collected before dialysis, and at 15 min and 4 hr after starting hemodialysis.
Gene_expression (levels) of C5a in dermis associated with pox virus infection, analgesic, pruritus and bradykinin
17) Confidence 0.58 Published 1989 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 2615018 Disease Relevance 0.32 Pain Relevance 0.36
Study on pruritus in hemodialysis patients and the antipruritic effect of neurotropin: plasma levels of C3a, C5a, bradykinin and lipid peroxides.
Gene_expression (levels) of C5a in plasma associated with pruritus and bradykinin
18) Confidence 0.58 Published 1989 Journal Nippon Jinzo Gakkai Shi Section Title Doc Link 2615018 Disease Relevance 0.35 Pain Relevance 0.41
This cellular receptor for C5a (CD88) is expressed in the liver, lung, kidney, and central nervous system [13, 14], with a single human neutrophil expressing 1–2 × 105 C5a receptors [1].
Gene_expression (expressed) of C5a in neutrophil associated with central nervous system
19) Confidence 0.39 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 1.10 Pain Relevance 0.33
This cellular receptor for C5a (CD88) is expressed in the liver, lung, kidney, and central nervous system [13, 14], with a single human neutrophil expressing 1–2 × 105 C5a receptors [1].
Gene_expression (expressed) of CD88 in neutrophil associated with central nervous system
20) Confidence 0.39 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 1.10 Pain Relevance 0.33

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