INT255034

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 7 54.28 Quite High
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 99.96 Very High Very High Very High
Diabetes Mellitus 95 98.26 Very High Very High Very High
Pancreatitis 81 89.28 High High
Hyperinsulinism 1 62.88 Quite High
Gastric Motility Disorder 1 30.92 Quite Low
Congenital Anomalies 3 22.28 Low Low
Hypoglycemia 16 20.16 Low Low
Insulin Resistance 8 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GLP-1 levels after DPP-4 inhibition are increased, resulting in stimulation of insulin secretion and suppression of glucagon secretion in a fashion which is glucose-dependent (ie, glucose-appropriate).
Positive_regulation (increased) of Negative_regulation (inhibition) of DPP-4
1) Confidence 0.37 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.12 Pain Relevance 0
In patients with T2DM, however, because the insulinotropic effect of GIP may be diminished in this disease, DPP-4 inhibitors are believed to mediate glucose lowering primarily via stabilisation of GLP-1 (5).
Positive_regulation (mediate) of Negative_regulation (inhibitors) of DPP-4 associated with diabetes mellitus and disease
2) Confidence 0.18 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2904489 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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