INT255042

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DPP4, GLP1R) small molecule metabolic process (GLP1R) Golgi apparatus (DPP4)
endoplasmic reticulum (DPP4) signal transducer activity (GLP1R) peptidase activity (DPP4)
DPP4 (Homo sapiens)
GLP1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 8 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 114 85.64 High High
Hypoglycemia 8 52.20 Quite High
Apoptosis 2 40.64 Quite Low
Obesity 10 17.00 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Hyperglycemia 10 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Cardiovascular Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DPP-4 inhibition increases not only prandial but also fasting levels of active GLP-1 and results in an overall increase in GLP-1 levels with maintenance of circadian rhythm throughout the day.
Negative_regulation (inhibition) of DPP-4 Positive_regulation (increases) of GLP-1
1) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.13 Pain Relevance 0
It could be demonstrated that DPP-4 inhibition increases circulating levels of GLP-1 in experimental animals and that the insulinotropic action of exogenously administered GLP-1 is intensified by DPP-4 inhibition (Holst and Deacon 1998).
Negative_regulation (inhibition) of DPP-4 Positive_regulation (increases) of GLP-1
2) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.20 Pain Relevance 0

General Comments

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