INT255044

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLP1R, INS) extracellular space (INS) extracellular region (INS)
plasma membrane (GLP1R) carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 2
alpha cells 2
sensory nerves 2
GLP1R (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 3 88.24 High High
potassium channel 2 80.40 Quite High
adenocard 4 73.20 Quite High
agonist 47 57.80 Quite High
Neuropeptide 4 31.08 Quite Low
headache 7 27.24 Quite Low
tolerance 7 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 171 99.92 Very High Very High Very High
Obesity 14 96.20 Very High Very High Very High
Disease 14 85.64 High High
Hypoglycemia 27 69.52 Quite High
Apoptosis 1 64.24 Quite High
Body Weight 19 45.44 Quite Low
Pressure And Volume Under Development 5 39.48 Quite Low
Disease Progression 10 33.28 Quite Low
Nasopharyngitis 6 29.76 Quite Low
Headache 7 27.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GLP-1 on the other hand is still able to stimulate insulin secretion under hyperglycaemia in type 2 diabetes [10].
GLP-1 Positive_regulation (stimulate) of Localization (secretion) of insulin associated with diabetes mellitus
1) Confidence 0.49 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.50 Pain Relevance 0.03
GLP-1 stimulates insulin secretion of the beta cells and additionally inhibits glucagon secretion from the alpha cells.
GLP-1 Positive_regulation (stimulates) of Localization (secretion) of insulin in alpha cells
2) Confidence 0.49 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.31 Pain Relevance 0.04
GLP-1 decreases glucose level by increasing insulin secretion in a glucose-dependent manner and by decreasing plasma glucagon concentrations.
GLP-1 Positive_regulation (increasing) of Localization (secretion) of insulin in plasma
3) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2878957 Disease Relevance 0.49 Pain Relevance 0
-cells, GLP-1 may also promote insulin secretion indirectly through the activation of sensory nerves (Ahrén 2004) suggesting an important neural contribution to GLP-1-induced insulin secretion, which could explain the rapid insulinotropic action after meal ingestion (Holst and Deacon 2005).
GLP-1 Spec (may) Positive_regulation (promote) of Localization (secretion) of insulin in sensory nerves
4) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.16 Pain Relevance 0.15

General Comments

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