INT25505

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
cleavage 1
phagocytes 1
Neutrophil 1
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 98.52 Very High Very High Very High
cINOD 3 53.04 Quite High
corticosteroid 2 46.00 Quite Low
Morphine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 98.52 Very High Very High Very High
Infection 24 97.76 Very High Very High Very High
Pneumonia 3 93.36 High High
Targeted Disruption 6 89.84 High High
Pressure And Volume Under Development 1 84.08 Quite High
Disease 9 80.96 Quite High
Hemolysis 9 70.52 Quite High
Sprains And Strains 3 57.04 Quite High
Communicable Diseases 6 5.00 Very Low Very Low Very Low
Bacterial Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection.
Protein_catabolism (degradation) of C5a associated with inflammation
1) Confidence 0.64 Published 1989 Journal J. Invest. Dermatol. Section Abstract Doc Link 2527912 Disease Relevance 0.31 Pain Relevance 0.11
The cleavage products of C5 are C5a, a potent chemoattractant, and C5b that initiates the lytic pathway.
Protein_catabolism (cleavage) of C5a in cleavage
2) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.09 Pain Relevance 0
Neutrophil influx and phagocytosis are inhibited by CHIPS, which binds the C5aR, and ScpA that cleaves C5a.
Protein_catabolism (cleaves) of C5a in Neutrophil
3) Confidence 0.12 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.47 Pain Relevance 0.13
ScpA cleaves C5a and blocks chemotaxis of phagocytes toward the site of infection [37].
Protein_catabolism (cleaves) of C5a in phagocytes associated with infection
4) Confidence 0.12 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.42 Pain Relevance 0

General Comments

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