INT255096

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Mbnl1) RNA binding (Mbnl1) nucleus (Mbnl1)
cytoplasm (Mbnl1)
Anatomy Link Frequency
neurons 2
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 32.24 Quite Low
GABAergic 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 2 96.04 Very High Very High Very High
Frailty 24 93.24 High High
Cognitive Disorder 1 75.32 Quite High
Muscle Disease 3 74.28 Quite High
Disease 14 52.08 Quite High
Spinocerebellar Ataxia Type 2 5 50.00 Quite Low
Targeted Disruption 38 48.76 Quite Low
Hypopituitarism 3 11.16 Low Low
Toxicity 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of the model that SCA8 CUGexp transcripts affect MBNL1 regulated pathways, expression of human SCA8 cDNA transcripts (ATXN8OS) in Drosophila photoreceptor neurons induce a late-onset, neurodegenerative phenotype genetically enhanced by the loss of the fly MBNL1 orthologue muscleblind [24].
Regulation (regulated) of Gene_expression (expression) of MBNL1 in neurons associated with neurodegenerative disease
1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.72 Pain Relevance 0
In these experiments no significant alteration in steady-state Mbnl1 levels were detected in ?
Neg (no) Regulation (alteration) of Gene_expression (levels) of Mbnl1
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

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