INT255097

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
myoblasts 2
nucleus 1
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 40.44 Quite Low
tolerance 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 48 91.44 High High
Toxicity 78 90.96 High High
Cytomegalovirus Infection 15 79.84 Quite High
Myotonia 42 78.24 Quite High
Arrhythmias 2 Under Development 30 76.80 Quite High
Frailty 30 74.96 Quite High
Targeted Disruption 111 66.32 Quite High
Cataract 24 63.72 Quite High
Myotonic Dystrophy 66 50.00 Quite Low
Congenital Anomalies 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the induction of the mutant 3’ UTR of DMPK in mice leads to accumulation of nuclear aggregates and to sequestration of MBNL1; these mice do not show overt DM1 phenotype [34].
Positive_regulation (induction) of DMPK
1) Confidence 0.61 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.76 Pain Relevance 0
Although the induction of the mutant 3’ UTR of DMPK in mice leads to accumulation of nuclear aggregates and to sequestration of MBNL1; these mice do not show overt DM1 phenotype [34].
Positive_regulation (induction) of DMPK
2) Confidence 0.44 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.76 Pain Relevance 0
Thus our data support the therapeutic use of small molecules that increase the transport of the mutant DMPK RNA from the nucleus into the cytoplasm as a means of greatly ameliorating DM1 pathology in vivo.


Positive_regulation (increase) of DMPK in nucleus
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.06 Pain Relevance 0
Expression of LacZ-(CUG)400 RNAs at levels equivalent to that of a DMPK mini gene encoding 300 CTG repeats does not result in aberrant RNA splicing in human myoblasts
Positive_regulation (equivalent) of DMPK mini gene in myoblasts
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.24 Pain Relevance 0
Expression of LacZ-(CUG)400 RNAs at levels equivalent to that of a DMPK mini gene encoding 300 CTG repeats does not result in aberrant RNA splicing in human myoblasts
Neg (not) Positive_regulation (result) of DMPK mini gene in myoblasts
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.25 Pain Relevance 0
Such reduction of the mutant DMPK mRNA export could be because of diminished capacity of the modification enzymes to process the mutant DMPK mRNA.
Positive_regulation (process) of mutant DMPK mRNA
6) Confidence 0.35 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox