INT255099

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Mbnl1) RNA binding (Mbnl1) nucleus (Mbnl1)
cytoplasm (Mbnl1)
Anatomy Link Frequency
heart 2
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 92.44 High High
tolerance 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 93.28 High High
Arrhythmias 2 Under Development 8 91.76 High High
Targeted Disruption 18 65.76 Quite High
Death 2 22.44 Low Low
Cv General 2 Under Development 4 21.44 Low Low
Heart Disease 4 12.60 Low Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that (i) CTG tracts expressed in a context independent manner can elicit elevated Cug-bp1 levels, (ii) a two fold elevation of Cug-bp1 levels is insufficient to dysregulate splice site choice in the adult mouse heart and (iii) aggregation of Mbnl1 in CUG foci per se may not be sufficient to inactivate Mbnl1.
Regulation (dysregulate) of Mbnl1 Binding (aggregation) of in heart
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.30 Pain Relevance 0.09

General Comments

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