INT255101

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 23
Total Number 60
Disease Relevance 11.91
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 6
muscle 2
myotubes 2
heart 2
cardiomyocytes 1
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 10 97.60 Very High Very High Very High
GABAergic 20 96.12 Very High Very High Very High
anesthesia 32 94.32 High High
imagery 20 94.28 High High
gABA 18 91.32 High High
Inflammation 38 69.52 Quite High
cytokine 76 54.64 Quite High
Central nervous system 76 5.00 Very Low Very Low Very Low
tolerance 50 5.00 Very Low Very Low Very Low
spastic colon 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1072 99.88 Very High Very High Very High
Toxicity 768 99.76 Very High Very High Very High
Congenital Anomalies 553 98.60 Very High Very High Very High
Disease 626 93.84 High High
Arrhythmias 2 Under Development 201 93.64 High High
Stress 38 91.96 High High
Arrhythmia Under Development 101 90.40 High High
Myotonic Dystrophy 876 89.44 High High
Hypopituitarism 74 89.04 High High
Frailty 368 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As noted above, CUGBP1-eIF2 complexes are increased in DM2 differentiating myotubes similar to normal myotubes (Fig. 6); suggesting that in DM2 myotubes, phosphorylation of CUGBP1 at Ser302 is normal.
Positive_regulation (increased) of CUGBP1 in myotubes
1) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.06 Pain Relevance 0.03
Recent data revealed that phosphorylation of CUGBP1 by PKC kinase also plays a significant role in the stabilization of CUGBP1 in DM1 cells [63].
Positive_regulation (stabilization) of CUGBP1
2) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
Since CUGBP1 mRNA levels are not increased in DM1 cells, it was suggested that CUG repeats may increase CUGBP1 stability.
Spec (may) Positive_regulation (increase) of CUGBP1
3) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0
The role of CUG repeats in the elevation of CUGBP1 in DM1 has been shown by examination of DM1 cellular and mouse models in which expression of CUG repeats led to the increase of CUGBP1 [34,39,63-65].
Positive_regulation (elevation) of CUGBP1
4) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.29 Pain Relevance 0
One of the molecular hallmarks of DM1 is the elevation of CUGBP1 protein and its RNA-binding activity [34,39,62,63].
Positive_regulation (elevation) of CUGBP1 protein
5) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.35 Pain Relevance 0
Given these multiple functions, it is expected that the increase of CUGBP1 in DM1 and in some patients with DM2 might change splicing, translation and stability of mRNAs, targets of CUGBP1.
Positive_regulation (increase) of CUGBP1
6) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.18 Pain Relevance 0
Early elevation of CUGBP1 in transgenic mice expressing CUG repeats shows that the increase of CUGBP1 is not a consequence of different abnormalities in DM1 but rather a direct result of expression of the mutant CUG repeats [64].
Positive_regulation (elevation) of CUGBP1 associated with targeted disruption and congenital anomalies
7) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.29 Pain Relevance 0
The elevation of CUGBP1 has been also reported for DM2 patients [52]; however, there are contradictory results for expression of CUGBP1 in DM2.
Positive_regulation (elevation) of CUGBP1
8) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.23 Pain Relevance 0
This suggests that elevation of CUGBP1 in DM1 and DM2 patients might increase HDAC1 levels which in turn might alter transcription of many genes.
Positive_regulation (elevation) of CUGBP1
9) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.18 Pain Relevance 0
This suggests that the increase of CUGBP1 or reduction of MBNL1 cause similar alterations of splicing in DM1 cells.
Positive_regulation (increase) of CUGBP1
10) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.26 Pain Relevance 0
Analysis of CUGBP1 stability in DM2 myoblasts and in normal cells expressing CCUG repeats showed that the stability of CUGBP1 is also increased in the presence of CCUG repeats [52].
Positive_regulation (increased) of CUGBP1 in myoblasts
11) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.05 Pain Relevance 0
Why the increase of CUGBP1 is toxic for cell functions?
Positive_regulation (increase) of CUGBP1
12) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Identification of all CUGBP1 mRNA targets involved in splicing, translation and RNA stability is the next important step to determine the toxicity of CUG/CCUG repeats associated with the elevation of CUGBP1.


Positive_regulation (elevation) of CUGBP1 associated with toxicity
13) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.43 Pain Relevance 0.03
CUGBP1 phosphorylated isoforms are increased in cytoplasm of DM2 myoblasts with elevated levels of CUGBP1; thus phosphorylation may also play a role in the stabilization of CUGBP1 in DM2 cells [52].
Positive_regulation (increased) of CUGBP1 in myoblasts
14) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
However, analysis of cytopasmic extracts from DM2 cultured myoblasts and from muscle biopsies of DM2 patients showed the elevation of CUGBP1 [52].
Positive_regulation (elevation) of CUGBP1 in muscle
15) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.14 Pain Relevance 0
In patients with DM1, CUGBP1 protein is increased without significant changes of CUGBP1 transcripts levels [39].
Positive_regulation (increased) of CUGBP1 protein
16) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.29 Pain Relevance 0
Early elevation of CUGBP1 in transgenic mice expressing CUG repeats shows that the increase of CUGBP1 is not a consequence of different abnormalities in DM1 but rather a direct result of expression of the mutant CUG repeats [64].
Positive_regulation (increase) of CUGBP1 associated with targeted disruption and congenital anomalies
17) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.28 Pain Relevance 0
CUGBP1 phosphorylated isoforms are increased in cytoplasm of DM2 myoblasts with elevated levels of CUGBP1; thus phosphorylation may also play a role in the stabilization of CUGBP1 in DM2 cells [52].
Positive_regulation (stabilization) of CUGBP1 in myoblasts
18) Confidence 0.56 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
The role of CUG repeats in the elevation of CUGBP1 in DM1 has been shown by examination of DM1 cellular and mouse models in which expression of CUG repeats led to the increase of CUGBP1 [34,39,63-65].
Positive_regulation (increase) of CUGBP1
19) Confidence 0.49 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.23 Pain Relevance 0
In fact, examination of CUGBP1 half-life in the presence of CUG repeats showed that CUG repeats stabilize CUGBP1 [39].
Positive_regulation (stabilize) of CUGBP1
20) Confidence 0.49 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0

General Comments

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