INT255102

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.47
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
Posterior 1
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 7 54.08 Quite High
anticonvulsant 2 12.00 Low Low
Pain 2 10.40 Low Low
abdominal pain 4 8.68 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 94.40 High High
Muscle Disease 7 91.80 High High
Hypopituitarism 65 91.28 High High
Cytomegalovirus Infection 7 89.24 High High
Toxicity 54 88.60 High High
Congenital Anomalies 33 82.56 Quite High
Disease 91 82.44 Quite High
Frailty 49 78.12 Quite High
Myotonic Dystrophy 80 75.76 Quite High
Cognitive Disorder 10 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
of the human DMPK termination codon, 3?
Transcription (codon) of DMPK
1) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.15 Pain Relevance 0
Initial reports using antisera and semiquantitative reverse transcriptase-polymerase chain reaction reported decreased levels of both DMPK mRNA and protein in adult forms of DM1, suggesting that large CTG repeat expansions altered DMPK mRNA synthesis and processing [15-18].
Transcription (synthesis) of DMPK
2) Confidence 0.58 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Posterior studies confirmed that DMPK transcription was altered in patients and that there was no correlation between CTG repeat length and DMPK protein reduction [23-25].
Transcription (transcription) of DMPK in Posterior
3) Confidence 0.58 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.27 Pain Relevance 0.03
Initial reports using antisera and semiquantitative reverse transcriptase-polymerase chain reaction reported decreased levels of both DMPK mRNA and protein in adult forms of DM1, suggesting that large CTG repeat expansions altered DMPK mRNA synthesis and processing [15-18].
Transcription (levels) of DMPK
4) Confidence 0.56 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.05 Pain Relevance 0
Other studies demonstrated that the mutant DMPK transcripts are completely blocked in nuclei [37,38].
Transcription (transcripts) of DMPK
5) Confidence 0.46 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Although CTG repeats affect expression of DMPK protein and the transcription of genes in the DMPK locus (recently reviewed in details in [24]), multisystemic nature of DM1 is mainly associated with the accumulation of non-coding CUG repeat RNA [25-34].
Transcription (transcription) of DMPK protein
6) Confidence 0.46 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.15 Pain Relevance 0
DMPK CUGexp transcripts form hairpin structures that are retained in nuclear foci in DM1 cells [8-10].
Transcription (transcripts) of DMPK
7) Confidence 0.39 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 1.17 Pain Relevance 0
However, subsequent improvements of protocols used for detection and quantification of total cytoplasmic mRNA levels reported that there was no significant change in DMPK transcription [21], and discovered that the anti-DMPK antisera used in previous reports crossreacted with other proteins [22].
Transcription (transcription) of DMPK
8) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.13 Pain Relevance 0
In DM1, MBNL1 binds to and is sequestered into nuclear foci by the mutant DMPK transcripts [14, 15].
Transcription (transcripts) of DMPK
9) Confidence 0.34 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.54 Pain Relevance 0

General Comments

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