INT255103

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Hnrnph1) RNA binding (Hnrnph1) nucleus (Hnrnph1)
cytoplasm (Hnrnph1)
Anatomy Link Frequency
stem 1
Hnrnph1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 8 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low
Heart Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 4 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, we have shown that siRNA mediated inactivation of MBNL1, which binds to the stem of the CUG hairpin, results in increased dispersion of nuclear foci in DM1 cells [46]. siRNA mediated reduction of hnRNP H, which binds to the base of the CUG hairpin, has also been demonstrated to allow transport of RNAs encoding expanded CUG repeats into the cytoplasm [51].
Negative_regulation (reduction) of hnRNP H in stem
1) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

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