INT255110

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.41
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
myoblasts 1
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 73.16 Quite High
Kinase C 4 64.64 Quite High
tolerance 20 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 80 93.92 High High
Cytomegalovirus Infection 30 90.56 High High
Disease 57 79.88 Quite High
Myotonic Dystrophy 38 75.00 Quite High
Arrhythmias 2 Under Development 52 72.48 Quite High
Targeted Disruption 143 72.40 Quite High
Sprains And Strains 26 65.76 Quite High
Cataract 21 51.08 Quite High
Hypopituitarism 28 49.52 Quite Low
Frailty 31 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant DMPK transcripts bind and sequester transcription factors such as Specificity protein 1 leading to reduced transcription of selected genes.
DMPK Binding (bind) of
1) Confidence 0.39 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.23 Pain Relevance 0
Consistent with these earlier results, inducible expression of high levels of interrupted CUG repeat tracts expressed in the context of the DMPK 3?
DMPK Binding (context) of
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.05 Pain Relevance 0
The relative lack of toxicity of cytoplasmic CUG RNA aggregates is unlikely to be a consequence of low expression levels, as an independent set of experiments carried out in human myoblasts demonstrate that when this transgene is expressed at similar levels to a second transgene in which the expanded CTG tract was expressed in the context of the DMPK 3?
DMPK Binding (context) of in myoblasts associated with toxicity
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.17 Pain Relevance 0.07
In this regard it is important to note a study by Mastroyiannopoulos and colleagues, which demonstrates that expanded CUG tracts when expressed in the context of the DMPK 3?
DMPK Binding (context) of
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.23 Pain Relevance 0
One might assume that, by analogy to these observations, the aggregation of the mutant DMPK mRNA in nuclei is likely mediated by a reduced processing of the mutant DMPK mRNA.
mutant DMPK mRNA Binding (aggregation) of
5) Confidence 0.28 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
UTR containing either 5 or 400 CTG repeats [GFP-DMPK 3?
DMPK Binding ([GFP) of
6) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.27 Pain Relevance 0
However, both our current study and those of others, demonstrate that expression of similar transgenes, in which GFP sequences are linked to the normal DMPK 3?
DMPK Binding (linked) of
7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.12 Pain Relevance 0
A noteworthy exception to this rule is the production of a DM1 phenocopy that results from the inducible expression of GFP sequences linked to the normal DMPK 3?
DMPK Binding (linked) of
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.20 Pain Relevance 0
The protein was identified in UV-crosslinking assays as a factor capable of binding and modulating nuclear retention of mutant DMPK mRNA.
DMPK Binding (binding) of
9) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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