INT255111

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Mbnl1) RNA binding (Mbnl1) nucleus (Mbnl1)
cytoplasm (Mbnl1)
Mbnl1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 54.80 Quite High
tolerance 9 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypopituitarism 3 97.48 Very High Very High Very High
Targeted Disruption 54 94.08 High High
Disease 9 86.28 High High
Heart Disease 12 73.72 Quite High
Frailty 9 65.44 Quite High
Arrhythmias 2 Under Development 24 58.72 Quite High
Toxicity 30 31.68 Quite Low
Congenital Anomalies 27 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 15 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abnormal splicing results from the functional inactivation of MBNL1, which is hypothesized to occur due to MBNL1 sequestration in CUG foci or from elevated levels of CUG-BP1.
Positive_regulation (results) of Positive_regulation (inactivation) of MBNL1
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597774 Disease Relevance 0.20 Pain Relevance 0.05
These data therefore demonstrate first, that functional inactivation of MBNL1 is sufficient to produce DM1 pathophysiology.
Positive_regulation (sufficient) of Positive_regulation (inactivation) of MBNL1
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.34 Pain Relevance 0
50% decrease in Mbnl1 is insufficient to alter splice site choice [32], these data demonstrate that aggregation per se cannot be the sole mechanism that underlies MBNL1 inactivation in DM1 cells.
Positive_regulation (underlies) of Positive_regulation (inactivation) of MBNL1
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox