INT255114

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 1
adult mouse 1
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 83.80 Quite High
Disease 6 81.36 Quite High
Hypopituitarism 2 59.04 Quite High
Toxicity 20 49.20 Quite Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 16 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Heart Disease 8 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus these results demonstrate that although increased steady state levels of CUG-BP1 is sufficient to produce features of DM1, elevated CUG-BP1 levels may not be required for DM1 pathology to manifest, as reduction of CUG-BP1 levels does not correct the splice defects in DM1 myoblasts.
Negative_regulation (reduction) of CUG-BP1 in myoblasts
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.29 Pain Relevance 0
Therefore, in adult mouse tissues very high levels of Cug-bp1 may be necessary to elicit splice defects.
Negative_regulation (levels) of Cug-bp1 in adult mouse
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

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