INT255116

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
myoblasts 2
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 91.44 High High
Toxicity 26 90.96 High High
Cytomegalovirus Infection 5 79.84 Quite High
Myotonia 14 78.24 Quite High
Arrhythmias 2 Under Development 10 76.80 Quite High
Frailty 10 74.96 Quite High
Targeted Disruption 37 66.32 Quite High
Cataract 8 63.72 Quite High
Myotonic Dystrophy 22 50.00 Quite Low
Congenital Anomalies 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the induction of the mutant 3’ UTR of DMPK in mice leads to accumulation of nuclear aggregates and to sequestration of MBNL1; these mice do not show overt DM1 phenotype [34].
Positive_regulation (induction) of Positive_regulation (induction) of DMPK
1) Confidence 0.44 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.76 Pain Relevance 0
Expression of LacZ-(CUG)400 RNAs at levels equivalent to that of a DMPK mini gene encoding 300 CTG repeats does not result in aberrant RNA splicing in human myoblasts
Positive_regulation (equivalent) of Neg (not) Positive_regulation (result) of DMPK mini gene in myoblasts
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.25 Pain Relevance 0

General Comments

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