INT255119

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 4
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 97.48 Very High Very High Very High
Inflammation 4 20.08 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
spastic colon 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 102 99.56 Very High Very High Very High
Disease 68 83.16 Quite High
Toxicity 76 78.80 Quite High
Hypopituitarism 12 70.76 Quite High
Myotonic Dystrophy 96 50.00 Quite Low
Congenital Anomalies 53 47.04 Quite Low
Cataract 33 42.28 Quite Low
Insulin Resistance 12 30.92 Quite Low
Frailty 34 30.00 Quite Low
INFLAMMATION 4 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CUGBP1 phosphorylated isoforms are increased in cytoplasm of DM2 myoblasts with elevated levels of CUGBP1; thus phosphorylation may also play a role in the stabilization of CUGBP1 in DM2 cells [52].
Positive_regulation (role) of Positive_regulation (stabilization) of CUGBP1 in myoblasts
1) Confidence 0.40 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
This suggests that elevation of CUGBP1 in DM1 and DM2 patients might increase HDAC1 levels which in turn might alter transcription of many genes.
Spec (might) Positive_regulation (increase) of Positive_regulation (elevation) of CUGBP1
2) Confidence 0.40 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.19 Pain Relevance 0
The elevation of CUGBP1 has been also reported for DM2 patients [52]; however, there are contradictory results for expression of CUGBP1 in DM2.
Positive_regulation (reported) of Positive_regulation (elevation) of CUGBP1
3) Confidence 0.40 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.23 Pain Relevance 0
Recent data revealed that phosphorylation of CUGBP1 by PKC kinase also plays a significant role in the stabilization of CUGBP1 in DM1 cells [63].
Positive_regulation (role) of Positive_regulation (stabilization) of CUGBP1
4) Confidence 0.37 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
Although the molecular mechanism leading to CUG-BP1 activation is not completely understood, inappropriate activation of the protein kinase C (PKC) pathway contributes to the pathogenic effect of noncoding CUG repeat RNA through hyperphosphorylation of nuclear CUG-BP1, which is stabilized in this cellular compartment [69].
Positive_regulation (leading) of Positive_regulation (activation) of CUG-BP1 associated with kinase c
5) Confidence 0.21 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.50 Pain Relevance 0.05
Thus these results demonstrate that although increased steady state levels of CUG-BP1 is sufficient to produce features of DM1, elevated CUG-BP1 levels may not be required for DM1 pathology to manifest, as reduction of CUG-BP1 levels does not correct the splice defects in DM1 myoblasts.
Positive_regulation (sufficient) of Positive_regulation (increased) of CUG-BP1 in myoblasts
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.27 Pain Relevance 0

General Comments

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