INT255125

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.84
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
skeletal muscle 2
myoblasts 1
heart 1
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 75.92 Quite High
medulla 2 42.76 Quite Low
GABAergic 20 36.80 Quite Low
imagery 20 7.76 Low Low
gABA 18 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 77 95.48 Very High Very High Very High
Frailty 61 92.88 High High
Muscle Disease 8 92.08 High High
Hypopituitarism 38 91.56 High High
Targeted Disruption 101 86.76 High High
Neuromuscular Disease 3 71.84 Quite High
Cataract 20 54.60 Quite High
Myotonic Dystrophy 46 50.00 Quite Low
Spinocerebellar Ataxia Type 2 10 50.00 Quite Low
Neurodegenerative Disease 4 15.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, stabilization of CUGBP1 in DM1 is achieved by a complex mechanism involving specific phosphorylation of CUGBP1, its interactions with un-aggregated CUG repeats, and possibly some other factors.
Localization (stabilization) of CUGBP1
1) Confidence 0.60 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
Identification of Cugbp1-Associated Transcripts
Localization (Identification) of Cugbp1
2) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0 Pain Relevance 0
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Localization (localizes) of CUG-BP1 in myoblasts
3) Confidence 0.31 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.59 Pain Relevance 0.04
In addition, CUGexp or CCUGexp transcripts accumulate as ribonuclear inclusions in DM1 and DM2 patient skeletal muscle [9]–[11] and alter the localization or regulation of RNA binding proteins CUGBP1 [12],[13] and MBNL1 [14],[15].
Localization (localization) of CUGBP1 in skeletal muscle
4) Confidence 0.28 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 1.01 Pain Relevance 0
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Localization (localizes) of CUG-BP1 in skeletal muscle
5) Confidence 0.11 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.59 Pain Relevance 0.04
CUG-BP1 and ETR-3 like factor (CELF) member CUG-BP1 does not bind ds(CUG) hairpins nor co-localizes with ribonuclear foci but its activity is increased in DM1 myoblasts, skeletal muscle, and heart tissues [36, 66, 67] (see [68] for a review about CELF RNA binding proteins).
Localization (localizes) of CUG-BP1 in heart
6) Confidence 0.11 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.59 Pain Relevance 0.04
In these experiments Cug-bp1 was found to localize primarily in the cytoplasm in both ?
Localization (localize) of Cug-bp1
7) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

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