INT255129

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 3.10
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
nucleus 3
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 3 86.24 High High
Kinase C 2 63.40 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
Central nervous system 18 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
spastic colon 9 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 12 97.28 Very High Very High Very High
Disease 139 95.08 Very High Very High Very High
Death 6 94.56 High High
Heart Disease 12 93.84 High High
Targeted Disruption 233 93.52 High High
Congenital Anomalies 126 93.48 High High
Fibrosis 3 86.24 High High
Toxicity 176 83.92 Quite High
Hypertrophy 15 83.52 Quite High
Dilated Cardiomyopathy 21 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
untranslated region of a protein kinase gene, DMPK, and is found 5?
Localization (region) of DMPK
1) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 1.06 Pain Relevance 0.04
960 interrupted CTG repeats located in the DMPK 3?
Localization (located) of DMPK
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.80 Pain Relevance 0
However, the formation of nuclear foci did not seem to interfere with the export of mutant DMPK mRNA from nuclei to cytoplasm [26].
Localization (export) of mutant DMPK mRNA
3) Confidence 0.61 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.05 Pain Relevance 0
Despite the nuclear aggregation of the mutant DMPK mRNA, a significant portion of this mRNA is still transported to cytoplasm [26,39,47].
Localization (aggregation) of mutant DMPK mRNA
4) Confidence 0.57 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
They found that the mutant DMPK mRNA is located at the periphery of nuclear speckles, suggesting that the efficiency of export of the mutant DMPK pre-mRNA is reduced [45,46].
Localization (located) of mutant DMPK mRNA
5) Confidence 0.57 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Several recent reports suggest that the nuclear aggregates of the mutant DMPK mRNA are not sufficient to cause DM1 phenotype.
Localization (aggregates) of mutant DMPK mRNA
6) Confidence 0.57 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.71 Pain Relevance 0
The primers sequences used for the amplification of LacZ-(CTG)0 or 400 and DMPK 11-15(CTG)5 or 300 are: LacZ-(CTG) 0 or 400 constructs (forward 5?
Localization (amplification) of DMPK
7) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.06 Pain Relevance 0
The main hypothesis of these studies was that the expanded RNA CTG repeats in the 3’ UTR of DMPK may interfere with transcription, post-transcriptional modifications (splicing, adenylation and cap formation) and export of the mutant DMPK mRNA from nucleus to cytoplasm.
Localization (export) of mutant DMPK mRNA in nucleus
8) Confidence 0.54 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.14 Pain Relevance 0
Data for the nucleus/cytoplasmic localization of mutant DMPK mRNA remain controversial.
Localization (localization) of mutant DMPK mRNA in nucleus
9) Confidence 0.54 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
Data for the nucleus/cytoplasmic localization of mutant DMPK mRNA remain controversial.
Localization (localization) of mutant DMPK mRNA in nucleus
10) Confidence 0.54 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0
One of the possible reasons for the existing controversies on the effect of CUG repeats on mutant DMPK nuclear-cytoplasmic export might be the sensitivity of assays.
Localization (export) of DMPK
11) Confidence 0.54 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Such reduction of the mutant DMPK mRNA export could be because of diminished capacity of the modification enzymes to process the mutant DMPK mRNA.
Localization (export) of mutant DMPK mRNA
12) Confidence 0.54 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
The protein was identified in UV-crosslinking assays as a factor capable of binding and modulating nuclear retention of mutant DMPK mRNA.
Localization (retention) of DMPK
13) Confidence 0.53 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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