INT255136

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 54.64 Quite High
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 37 99.88 Very High Very High Very High
Toxicity 26 89.44 High High
Arrhythmias 2 Under Development 10 56.64 Quite High
Death 2 56.44 Quite High
Cv General 2 Under Development 4 55.44 Quite High
Myotonic Dystrophy 22 50.00 Quite Low
Disease 16 50.00 Quite Low
Heart Disease 4 46.60 Quite Low
Hypertrophy 3 36.28 Quite Low
Congenital Anomalies 20 22.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both in DM1 cells and in transgenic mice demonstrating cardiac specific expression of expanded CTG tracts located in the DMPK 3?
Regulation (demonstrating) of Gene_expression (expression) of DMPK associated with targeted disruption
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.41 Pain Relevance 0.05
Although CTG repeats affect expression of DMPK protein and the transcription of genes in the DMPK locus (recently reviewed in details in [24]), multisystemic nature of DM1 is mainly associated with the accumulation of non-coding CUG repeat RNA [25-34].
Regulation (affect) of Gene_expression (expression) of DMPK protein
2) Confidence 0.24 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.15 Pain Relevance 0

General Comments

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