INT255145

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Mbnl1, Hnrnph1) RNA binding (Mbnl1, Hnrnph1) nucleus (Mbnl1, Hnrnph1)
cytoplasm (Mbnl1, Hnrnph1)
Mbnl1 (Mus musculus)
Hnrnph1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 2 73.28 Quite High
Targeted Disruption 36 5.00 Very Low Very Low Very Low
Toxicity 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 16 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Heart Disease 8 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 8 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a cadre of drugs is attractive as they may prove to be less toxic, when compared to small molecules that abolish the interaction of these proteins with the mutant DMPK RNA, as their disruptive effect on MBNL1 or hnRNP H interactions with their normal target RNAs may be less severe.


MBNL1 Binding (interactions) of hnRNP H
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.07 Pain Relevance 0
Such a cadre of drugs is attractive as they may prove to be less toxic, when compared to small molecules that abolish the interaction of these proteins with the mutant DMPK RNA, as their disruptive effect on MBNL1 or hnRNP H interactions with their normal target RNAs may be less severe.


MBNL1 Binding (interactions) of hnRNP H
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.07 Pain Relevance 0

General Comments

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