INT25517

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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 9
Speculated 3
Reported most in Abstract
Documents 41
Total Number 43
Disease Relevance 22.28
Pain Relevance 16.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
keratinocytes 4
SH-SY5Y 2
chondrocytes 1
immune cells 1
neurons 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 95 100.00 Very High Very High Very High
cytokine 50 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
qutenza 16 100.00 Very High Very High Very High
tramadol 7 100.00 Very High Very High Very High
chemokine 3 99.56 Very High Very High Very High
nMDA receptor 7 99.44 Very High Very High Very High
cINOD 35 99.12 Very High Very High Very High
noradrenaline 1 98.96 Very High Very High Very High
dexamethasone 6 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 122 100.00 Very High Very High Very High
Cancer 50 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Autoimmune Disease 6 99.92 Very High Very High Very High
Stress 22 99.82 Very High Very High Very High
Obesity 68 99.78 Very High Very High Very High
Breast Cancer 2 99.46 Very High Very High Very High
Esophageal Cancer 2 99.42 Very High Very High Very High
Skin Cancer 16 99.40 Very High Very High Very High
Alzheimer's Dementia 3 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Can NF-kappaB be a target for novel and efficient anti-cancer agents?
Regulation (target) of NF-kappaB associated with cancer
1) Confidence 0.61 Published 2006 Journal Biochem. Pharmacol. Section Title Doc Link 16973133 Disease Relevance 0.55 Pain Relevance 0.15
Apart from the inhibition of prostanoid synthesis aspirin shows a variety of pharmacological activities, including reduction of ATP storage pools, increased extracellular adenosine, lowered inducible nitric oxide synthase activity, modulation of mitogen-activated protein kinases, and the expression of a plethora of genes induced under conditions of cell stress via the regulation of transcription factor NFkappaB activity.
Regulation (regulation) of NFkappaB associated with stress, aspirin and adenocard
2) Confidence 0.60 Published 2005 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 15928593 Disease Relevance 0.25 Pain Relevance 0.59
This article begins by summarising current understanding of these pathways at a molecular level, and then focuses on the importance of ubiquitination and deubiquitination during the regulation of the pro-inflammatory transcription factor NF-kappaB.
Regulation (regulation) of NF-kappaB associated with inflammation
3) Confidence 0.60 Published 2005 Journal Expert Rev Mol Med Section Abstract Doc Link 15967057 Disease Relevance 0.34 Pain Relevance 0.30
We also propose that the expression of coexisting symptoms is linked to the deregulated activity of nuclear factor-kappa B, the transcription factor responsible for the production of cytokines and mediators of the inflammatory responses due to cancer and/or cancer treatment.
Regulation (deregulated) of nuclear factor-kappa B associated with inflammatory response, cancer, immunotherapy of cancer and cytokine
4) Confidence 0.58 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15316238 Disease Relevance 1.04 Pain Relevance 0.44
In conclusion, we show that structurally different compounds, among which are celecoxib and PSC833, increase the intracellular accumulation of dox and enhance dox induced cytotoxicity in MDA-MB231 breast cancer cells most likely via the modulation of NF-kappaB activity.
Regulation (modulation) of NF-kappaB associated with breast cancer
5) Confidence 0.56 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.10 Pain Relevance 0
We aimed to observe the effects of morphine, fentanyl and tramadol on NF-kappa B and IL-2 from both laboratory and clinical perspective.
Regulation (effects) of NF-kappa B associated with tramadol and morphine
6) Confidence 0.56 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 0.93
Redox regulation of NF-kappa B has been implicated in the activation of the human immuno-deficiency virus (HIV).
Regulation (regulation) of kappa B associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.49 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8573121 Disease Relevance 0.41 Pain Relevance 0.07
CONCLUSIONS: These data show that NF-kappaB is specifically and significantly activated in unstable angina pectoris and is not affected by severity of CAD or medical therapy.
Neg (not) Regulation (affected) of NF-kappaB
8) Confidence 0.45 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
Neg (no) Regulation (effects) of p50
9) Confidence 0.44 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.30 Pain Relevance 0.24
Opioids and the neuropeptide substance P (SP) modulate the expression of inflammatory cytokines and chemokines, which are under the control of nuclear factor kappaB (NF-kappaB).
Regulation (control) of NF-kappaB associated with chemokine, inflammation, neuropeptide, opioid, cytokine and substance p
10) Confidence 0.44 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.10 Pain Relevance 1.06
Opioids and the neuropeptide substance P (SP) modulate the expression of inflammatory cytokines and chemokines, which are under the control of nuclear factor kappaB (NF-kappaB).
Regulation (control) of nuclear factor kappaB associated with chemokine, inflammation, neuropeptide, opioid, cytokine and substance p
11) Confidence 0.44 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.10 Pain Relevance 1.06
The effects of estrogen on distinct intracellular signaling pathways including MAPK, PI3K/AKT and NF-kappa B may take a role in enhanced endometrial cell survival, altered immune response, and differential cytokine and chemokine expression in endometriosis.
Regulation (effects) of NF-kappa B associated with endometriosis, chemokine and cytokine
12) Confidence 0.44 Published 2009 Journal Front Biosci (Elite Ed) Section Abstract Doc Link 19482657 Disease Relevance 1.07 Pain Relevance 0.50
We also propose that the expression of coexisting symptoms is linked to the deregulated activity of nuclear factor-kappa B, the transcription factor responsible for the production of cytokines and mediators of the inflammatory responses due to cancer and/or cancer treatment.
Regulation (deregulated) of nuclear factor-kappa B associated with inflammatory response, cancer, immunotherapy of cancer and cytokine
13) Confidence 0.43 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15316238 Disease Relevance 1.04 Pain Relevance 0.44
Neither agent by itself activated NF-kappa B or affected the DNA-binding ability of NF-kappa B.
Neg (Neither) Regulation (affected) of NF-kappa B
14) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.07 Pain Relevance 0.75
Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.
Regulation (Regulation) of NF-kappaB associated with qutenza and skin cancer
15) Confidence 0.42 Published 2002 Journal J. Interferon Cytokine Res. Section Title Doc Link 12034025 Disease Relevance 0.63 Pain Relevance 0.47
Both compounds mediate their effects by targeting the NF-kappaB signalling pathway.
Regulation (targeting) of NF-kappaB
16) Confidence 0.42 Published 2009 Journal Arthritis Res. Ther. Section Abstract Doc Link 19889203 Disease Relevance 0.59 Pain Relevance 0.35
METHODS: We have recently demonstrated that in chondrocytes resveratrol modulates the NF-kappaB pathway by inhibiting the proteasome, while curcumin modulates the activation of NF-kappaB by inhibiting upstream kinases (Akt).
Regulation (modulates) of NF-kappaB in chondrocytes
17) Confidence 0.42 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.09 Pain Relevance 0
Although in humans NMDA receptors may not be involved in the regulation of PPI and P50 reduction, the most likely explanation for the lack of effect of ketamine on these sensory gating paradigms is the dose used in this experiment.
Regulation (regulation) of P50 associated with ketamine and nmda receptor
18) Confidence 0.39 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.24 Pain Relevance 0.74
These results indicate that SDX-308 effectively inhibits multiple myeloma cell proliferation and osteoclast activity, potentially by controlling NF-kappaB activation signaling.
Regulation (controlling) of NF-kappaB in osteoclast associated with multiple myeloma
19) Confidence 0.37 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.77 Pain Relevance 0.10
Since these gene products are regulated by the transcription factor NF-kappaB, we investigated the effects of resveratrol on IL-1beta-induced NF-kappaB signaling pathway.
Spec (investigated) Regulation (resveratrol) of NF-kappaB
20) Confidence 0.37 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.14 Pain Relevance 0.37

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