INT2552

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Context Info
Confidence 0.15
First Reported 1979
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.48
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)
Anatomy Link Frequency
nerve 1
vas deferens 1
hippocampus 1
Fdft1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 82 100.00 Very High Very High Very High
Clonidine 20 99.76 Very High Very High Very High
Hippocampus 16 99.54 Very High Very High Very High
antagonist 8 98.28 Very High Very High Very High
Neuropeptide 2 91.08 High High
Calcium channel 4 84.64 Quite High
conotoxin 2 81.92 Quite High
tetrodotoxin 2 77.84 Quite High
narcan 2 76.68 Quite High
agonist 4 74.04 Quite High
Disease Link Frequency Relevance Heat
Decapitation 2 92.12 High High
Bordatella Infection 2 83.36 Quite High
Neuropathic Pain 2 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results were taken as an indication that SS produces its inhibitory action in the rat vas deferens by interacting with specific SS and its receptors presumably located in the cell membranes of adrenergic nerve terminals.
SS Binding (interacting) of in vas deferens associated with somatostatin
1) Confidence 0.15 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 467493 Disease Relevance 0 Pain Relevance 0.51
The interaction between SS and its receptors may provoke a decreased diffusion of Ca2+ ions into the nerve terminals and/or a decreased mobilisation of Ca2+ ions from intraneuronal stores thus leading to a reduction in electrically evoked release of norepinephrine.
SS Binding (interaction) of in nerve associated with somatostatin
2) Confidence 0.15 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 467493 Disease Relevance 0 Pain Relevance 0.49
The increased ACh release in the presence of either peptide appeared to be mediated by an interaction with SS receptors because cyclo-SS, a putative SS antagonist, abolished the effects of both SS-28 and SS-14.
SS Spec (appeared) Binding (interaction) of associated with antagonist and somatostatin
3) Confidence 0.13 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.09
The results suggest that in the rat hippocampus, both SS-28 and SS-14 interact with SS receptors to regulate ACh release indirectly by a mechanism that involves alterations of calcium influx during depolarization.
SS Binding (interact) of in hippocampus associated with somatostatin and hippocampus
4) Confidence 0.10 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.13
This change in SS binding was not the result of a direct effect of clonidine on these receptors because no effect in binding was produced by high concentrations of clonidine (10(-5) M) when added in vitro.
SS Binding (binding) of associated with somatostatin and clonidine
5) Confidence 0.09 Published 1995 Journal Neuropsychopharmacology Section Abstract Doc Link 7766286 Disease Relevance 0.16 Pain Relevance 1.27
Pretreatment with yohimbine prevented the clonidine-induced in SS binding.
SS Binding (binding) of associated with somatostatin and clonidine
6) Confidence 0.09 Published 1995 Journal Neuropsychopharmacology Section Abstract Doc Link 7766286 Disease Relevance 0.17 Pain Relevance 1.38
The monoamine re-uptake inhibition effects (ESS-M1,T) were modelled as an indirect response model incorporating a competitive interaction between SS-T and SS-M1.
SS-M1 Binding (interaction) of
7) Confidence 0.02 Published 2008 Journal Pharm. Res. Section Body Doc Link 18008149 Disease Relevance 0.15 Pain Relevance 0

General Comments

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