INT255257

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Mus musculus)
Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 69.84 Quite High
cytokine 8 54.88 Quite High
tolerance 6 48.44 Quite Low
chemokine 2 22.28 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 20 90.56 High High
INFLAMMATION 84 69.84 Quite High
Cancer 38 65.56 Quite High
Inflammatory Bowel Disease 40 65.12 Quite High
Adhesions 6 41.72 Quite Low
Metastasis 8 8.24 Low Low
Carcinoma 10 5.52 Low Low
Colon Cancer 20 5.00 Very Low Very Low Very Low
Adenoma 14 5.00 Very Low Very Low Very Low
Colitis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TSP1 is involved in the formation and resolution of a fibrin clot and binds to many proteins and proteases.(16) TSP1 interacts with heparan sulfates, proteoglycans, integrins, fibrinogen and fibronectin.(18) It also binds to components of the fibrinolytic system (plasminogen, urokinase and its inhibitor PAI-1)(19,20) and to cathepsin G and elastase.(21)
PAI-1 Binding (interacts) of TSP1
1) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.39 Pain Relevance 0.09
TSP1 is involved in the formation and resolution of a fibrin clot and binds to many proteins and proteases.(16) TSP1 interacts with heparan sulfates, proteoglycans, integrins, fibrinogen and fibronectin.(18) It also binds to components of the fibrinolytic system (plasminogen, urokinase and its inhibitor PAI-1)(19,20) and to cathepsin G and elastase.(21)
PAI-1 Binding (binds) of TSP1
2) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.46 Pain Relevance 0.12

General Comments

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